- ►diabetesjournals.org D Le Roith, Y Zick - Diabetes Care, 2001 - Am Diabetes Assoc Insulin signaling at the target tissue results in a large array of biological
outcomes. These events are essential for normal growth and development and for
normal homeostasis of glucose, fat, and protein metabolism. Elucidating the ... Cited by 194 - Related articles - BL Direct - All 5 versions
Y Zick, C LEVEL - Diabetes Care, 2001 - Am Diabetes Assoc I nsulin signaling at the target tissue re- sults in a large array of biological
out- comes. These events are essential for normal growth and development and for
normal homeostasis of glucose, fat, and protein metabolism. Elucidating the ... Related articles
Y Zick - Trends in cell biology, 2001 - Elsevier Insulin resistance refers to a decreased capacity of circulating insulin to
regulate nutrient metabolism. It is associated with the development of type 2
diabetes – an ever-increasing epidemic of the 21st century. Recent ... Cited by 156 - Related articles - BL Direct - All 8 versions
- ►jbc.org K Paz, R Hemi, D LeRoith, A Karasik, E … - Journal of Biological Chemistry, 1997 - ASBMB Tumor necrosis factor (TNF ) or chronic hyperinsulinemia that induce insulin
resistance trigger increased Ser/Thr phosphorylation of the insulin receptor
(IR) and of its major insulin receptor substrates, IRS-1 and IRS-2. To ... Cited by 288 - Related articles - BL Direct - All 4 versions
- ►whitelabs.org [PDF] YH Lee, J Giraud, RJ Davis, MF White - Journal of Biological Chemistry, 2003 - ASBMB Activation of the c-Jun N-terminal kinase (JNK) by proinflammatory cytokines
inhibits insulin signaling, at least in part, by stimulating phosphorylation of
rat/mouse insulin receptor substrate 1 (Irs1) at Ser 307 (Ser 312 in human ... Cited by 186 - Related articles - BL Direct - All 6 versions
L Qiao, R Zhande, TL Jetton, G Zhou, XJ Sun - Journal of Biological Chemistry, 2002 - ASBMB Insulin resistance is a key pathophysiologic feature of obesity and type 2
diabetes and is associated with other human diseases, including atherosclerosis,
hypertension, hyperlipidemia, and polycystic ovarian disease. Yet, the ... Cited by 74 - Related articles - BL Direct - All 5 versions
K PAZ, Y ZICK - Insulin signaling: from cultured cells to animal models, 2002 - books.google.com 14. SER/THR PHOSPHORYIATION OF INSULIN RECEPTOR SIGNALING MOLECULES AND INSULIN
RESISTANCE KEREN PAZ AND YEHIEL ZICK* Department of Molecular Cell Biology, The
Weizmann Institute of Science, Rehovot, 76100, Israel INTRODUCTION Insulin ... Related articles
- ►jbc.org YF Liu, K Paz, A Herschkovitz, A Alt, T … - Journal of Biological Chemistry, 2001 - ASBMB Incubation of rat hepatoma Fao cells with insulin leads to a transient rise in
Tyr phosphorylation of insulin receptor substrate (IRS) proteins. This is
followed by elevation in their P-Ser/Thr content, and their dissociation ... Cited by 154 - Related articles - BL Direct - All 5 versions
- ►endojournals.org GP Sykiotis, AG Papavassiliou - Molecular Endocrinology, 2001 - Endocrine Soc Insulin resistance, the failure to respond to normal circulating concentrations
of insulin, is a common state associated with obesity, aging, and a sedentary
lifestyle. Compelling evidence implicates TNF as the cause and link between ... Cited by 62 - Related articles - BL Direct - All 2 versions
K Paz, YF Liu, H Shorer, R Hemi, D LeRoith, … - Journal of Biological Chemistry, 1999 - ASBMB Incubation of cells with insulin leads to a transient rise in Tyr
phosphorylation of insulin receptor substrate (IRS) proteins, accompanied by
elevation in their Ser(P)/Thr(P) content and their dissociation from the ... Cited by 159 - Related articles - BL Direct - All 4 versions
