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Scholar Results 1 - 10 of about 101 related to Knowles: Insulin and amylin release are both diminished in first-degree relatives of subjects.... (0.11 sec) 

Insulin and amylin release are both diminished in first-degree relatives of subjects …


NG Knowles, MA Landchild, WY Fujimoto, SE Kahn - Diabetes Care, 2002 - Am Diabetes Assoc
RESULTS—Fasting plasma glucose (5.3 ± 0.1 vs. 5.1 ± 0.1 mmol/l; means ± SEM), immunoreactive
insulin (IRI) (68 ± 7 vs. 57 ± 6 pmol/l) and amylin-like immunoreactivity (ALI) (5.5 ± 0.6 vs. 4.7
± 0.7 pmol/l) were similar in relatives and control subjects, respectively. Relatives were ...
Cited by 24 - Related articles - BL Direct - All 6 versions

[PDF] Reduced amylin release is a characteristic of impaired glucose tolerance and type …


SE Kahn, CB Verchere, S Andrikopoulos, PJ … - DIABETES-NEW …, 1998 - Am Diabetes Assoc
Islet amyloid is a characteristic feature of type 2 dia- betes. Its major component is the normal
-cell secretory product amylin, or islet amyloid polypeptide (IAPP). To determine whether increased
or disproportionate release of amylin may explain the propensity for amy- loid deposition ...
Cited by 42 - Related articles - BL Direct - All 4 versions

Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and …


S Enoki, T Mitsukawa, J Takemura, M … - Diabetes Res Clin …, 1992 - grande.nal.usda.gov
Record Detail. Return to previous page, Save: Title: Plasma islet amyloid polypeptide
levels in obesity, impaired glucose tolerance and non-insulin-dependent diabetes
mellitus. Author: Enoki, S : Mitsukawa, T : Takemura, J : Nakazato ...
Cited by 39 - Related articles - Cached - All 3 versions

Deficiency of total and nonglycosylated amylin in plasma characterizes subjects …

- endojournals.org
S Makimattila, MS Fineman, H Yki-Jarvinen - Journal of Clinical …, 2000 - Endocrine Soc
This study was undertaken to characterize first and second phase secretory profiles of total and
nonglycosylated amylin and insulin and to determine whether excessive glycosylation of amylin
or hyperamylinemia is a feature of abnormal glucose tolerance in humans. Plasma ...
Cited by 10 - Related articles - BL Direct - All 4 versions

Elevated islet amyloid pancreatic polypeptide and proinsulin in lean gestational …


A Kautzky-Willer, K Thomaseth, B Ludvik, P Nowotny, D … - Diabetes, 1997 - Am Diabetes Assoc
Recent research indicates that islet amyloid pancreatic polypeptide (IAPP) might have a regulatory
effect on beta-cell insulin processing and secretion. To study such interaction in more detail,
IAPP secretion and kinetics and the serum concentrations of proinsulin were assessed ...
Cited by 33 - Related articles - BL Direct - All 4 versions

Human aging is associated with parallel reductions in insulin and amylin release

- physiology.org
… , CB Verchere, S Andrikopoulos, SE Kahn - American Journal of …, 1998 - Am Physiological Soc
Aging is associated with an increased risk of type 2 diabetes. To determine whether the insulin
resistance of aging is associated with an increase in amylin release or whether amylin release
parallels the reduction in insulin release, we studied 10 older (72 ± 2 yr) and 9 young (25 ...
Cited by 27 - Related articles - BL Direct - All 5 versions

Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B- …


SE Kahn, WY Fujimoto, DA D'Alessio, JW Ensinck … - Horm Metab …, 1991 - thieme-connect.com
Islet amyloid polypeptide (IAPP) has been shown to be actively secreted by the pancreatic
B-cell along with insulin. To determine whether the modulation of B-cell IAPP secretion is similar
to that of insulin, we assessed IAPP release in response to glucose at 4 different ...
Cited by 16 - Related articles - All 4 versions

[CITATION] Increased ß-cell secretory demand is not the simple explanation for inefficient …


MJ Landchild, NG Knowles, Q Yao, CE Walden, BM … - J Invest Med, 2000
Cited by 3 - Related articles

2 型糖尿病一级亲属不同糖耐量者第一时相胰岛素分泌功能的变化


严励, 陈黎红, 何扬, 唐菊英, 黎锋, 刘湘茹, 程桦 - 中国病理生理杂志, 2005 - cqvip.com
目的:探讨胰岛素分泌功能和胰岛素抵抗(IR)在2型糖尿病(T2DM)发生、发展中的作用.方法:T2DM
一级亲属正常糖耐量(NGT+)组32例,T2DM一级亲属糖耐量异常(IGT+)组36例,新诊断的T2DM
组35例,计算各组的第一时相胰岛素分泌功能指数(AIR3-5)及胰岛素敏感性指数(SIM),与无糖尿病 ...
Cited by 3 - Related articles - All 4 versions

Role of islet amyloid polypeptide secretion in insulin-resistant humans


A Kautzky-Willer, K Thomaseth, G Pacini, M Clodi, B … - Diabetologia, 1994 - Springer
Summary Although it is generally accepted that islet amyloid polypeptide is cosecreted with
insulin, rela- tively few data on its kinetics are available. We there- fore studied the dynamics
of islet amyloid polypeptide release following oral and frequently sampled in- travenous ...
Cited by 49 - Related articles - BL Direct - All 3 versions


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