R Kotani, M Nagata, H Moriyama, M Nakayama … - Diabetes Care, 2002 - Am Diabetes Assoc RESULTS—Significant proliferative responses to GAD65 were observed in 10 of 31
(32.3%) type 1 diabetic patients (P < 0.05), whereas GAD65-reactive
γ-interferon (IFN-γ)-secreting cells were detected in 22 of 33 patients ... Cited by 20 - Related articles - BL Direct - All 7 versions
NC Schloot, G Meierhoff, M Karlsson Faresjö … - Journal of Autoimmunity, 2003 - Elsevier The identification of sensitive assay formats capable of distinguishing islet
autoreactive T cells directly ex vivo in blood is a major goal in type 1
diabetes research. Recently, much interest has been shown in the cytokine ... Cited by 43 - Related articles - All 4 versions
M Masuda, M Powell, S Chen, C Beer, P … - Clinica Chimica Acta, 2000 - Elsevier An immunoprecipitation assay for autoantibodies (Abs) to the human islet cell
antigen IA-2 has been developed using 125 I-labelled recombinant IA-2 expressed
in E. coli. With this assay IA-2 Abs were detected in 103/217 (47%) of IDDM ... Cited by 29 - Related articles - All 5 versions
G Meierhoff, PA Ott, PV Lehmann, NC Schloot - Diabetes/Metabolism Reviews - interscience.wiley.com Diabetes mellitus type 1 is a chronic disease in which the insulin-secreting
ß-cells are selectively destroyed by an immune-mediated process. Autoantibodies
directed against several islet antigens are useful parameters to estimate ... Cited by 24 - Related articles - BL Direct - All 3 versions
R Kotani, M Nagata, A Imagawa, H Moriyama, … - Diabetologia, 2004 - Springer Aims/hypothesis. Fulminant Type 1 diabetes is a novel subtype of Type 1 diabetes
that involves the abrupt onset of insulin-deficient hyperglycaemia. This sub-
type appears to be non-autoimmune because of the ab- sence of ... Cited by 24 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Peakman, TI Tree, J Endl, P van Endert, … - Diabetes, 2001 - Am Diabetes Assoc The identification, quantification, and characterization of T-cells reactive
with the islet autoantigens GAD65, proinsulin (PI), and tyrosine
phosphatase–like molecules IA-2 and phogrin are major research goals in ... Cited by 50 - Related articles - BL Direct - All 5 versions
S RATHMANN, T RAJASALU, S ROSINGER, … - Ann. NY Acad. Sci, 2004 - cmbi.bjmu.edu.cn ABSTRACT: In animal models autoreactive CD8 T cells are crucial in the
development of type 1 diabetes (T1D); however, their role in human T1D is still
not known. To address the role of CD8 T cells we performed a pilot study by ... Cited by 8 - Related articles - View as HTML - All 8 versions
- ►alaskaclinicaltrials.org [PDF] V Öling, J Marttila, J Ilonen, WW Kwok, G … - Journal of Autoimmunity, 2005 - Elsevier In type 1 diabetes the major loss of insulin producing beta-cells is caused by
autoreactive T-cells specific for antigens expressed by the pancreatic islets.
In this study we have analyzed the prevalence of glutamate decarboxylase 65 ... Cited by 23 - Related articles - All 8 versions
A Shimada, K Kodama, J Morimoto, Y Oikawa, … - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2003 - interscience.wiley.com Abstract: Objective—Although the majority of type 1 diabetes is considered to
be type 1A, some patients with type 1 diabetes have no islet-associated
autoantibody in their serum. This type of type 1 diabetes has usually been ... Cited by 10 - Related articles - BL Direct - All 5 versions
[CITATION] Participating Laboratories: Combined use of autoantibodies (IA-2 autoantibody, GAD …
