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Scholar Results 1 - 10 of about 101 related to Ahrén: Characterization of GLP-1 effects on β-cell function after meal ingestion in humans. (0.09 sec) 

Characterization of GLP-1 effects on β-cell function after meal ingestion in humans

- diabetesjournals.org
B Ahrén, JJ Holst, A Mari - Diabetes Care, 2003 - Am Diabetes Assoc
RESULTS—GLP-1 markedly augmented insulin secretion, despite lower glucose. Total insulin
secretion was 29.7 ± 4.2 nmol/m 2 with GLP-1 versus 21.0 ± 1.6 nmol/m 2 with saline (P =
0.048). GLP-1 increased the dose-response relationship between glucose concentration ...
Cited by 28 - Related articles - BL Direct - All 5 versions

Assessing insulin secretion by modeling in multiple-meal tests

- diabetesjournals.org
A Mari, A Tura, A Gastaldelli, E Ferrannini - Diabetes, 2002 - Am Diabetes Assoc
We developed a mathematical model of the glucose control of insulin secretion capable of quantifying
β-cell function from a physiological meal test. The model includes a static control, ie, a secretion
component that is a function of plasma glucose concentration (the dose-response ...
Cited by 64 - Related articles - BL Direct - All 4 versions

Meal and oral glucose tests for assessment of beta-cell function: modeling analysis …

- physiology.org
A Mari, O Schmitz, A Gastaldelli, T … - American Journal of …, 2002 - Am Physiological Soc
We investigated -cell function and its relationship to insulin sensitivity in 17 normal
volunteers. For insulin secretion (derived by C-peptide deconvolution), a mathematical model
was applied to 24-h triple-meal tests (MT) as well as oral glucose tolerance tests (OGTT); ...
Cited by 89 - Related articles - BL Direct - All 5 versions

Impact of incretin hormones on beta-cell function in subjects with normal or …

- physiology.org
E Muscelli, A Mari, A Natali, BD Astiarraga … - American Journal of …, 2006 - Am Physiological Soc
The mechanisms by which the enteroinsular axis influences -cell function have not been investigated
in detail. We performed oral and isoglycemic intravenous (IV) glucose administration in subjects
with normal (NGT; n = 11) or impaired glucose tolerance (IGT; n = 10), using C-peptide ...
Cited by 20 - Related articles - BL Direct - All 4 versions

Characterization of {beta}-cell function impairment in first-degree relatives of type 2 …

- physiology.org
A Mari, A Gastaldelli, A Natali, T Ostergard … - American Journal of …, 2005 - Am Physiological Soc
To investigate early secretory defects in prediabetes, we evaluated -Cell function and insulin
sensitivity (M value, by euglycemic clamp) in 26 normotolerant first-degree relatives of type 2
diabetic patients (FDR) and 17 age- and weight-matched control subjects. -Cell function ...
Cited by 10 - Related articles - All 6 versions

[PDF] A model for glucose control of insulin secretion during 24 h of free living


A Mari, S Camastra, E Toschi, A Giancaterini, … - DIABETES-NEW …, 2001 - Am Diabetes Assoc
The aim of this work was to develop a mathematical model describing the functional dependence
of insulin secretion on plasma glucose concentrations during 24 h of free living. We obtained
hourly central venous blood samples from a group of healthy volunteers who spent 24 h ...
Cited by 26 - Related articles - BL Direct - All 4 versions

[CITATION] NVP-LAF237, a dipeptidyl peptidase IV inhibitor, improves glucose tolerance and …


B Dardik, M Valentin, C Schwartzkopf, C Gutierrez, D … - Diabetes, 2003
Cited by 15 - Related articles

Mathematical modeling shows exenatide improved β-cell function in patients with …


A Mari, LL Nielsen, N Nanayakkara, RA DeFronzo, … - Hormone and metabolic …, 2006 - cat.inist.fr
The incretin mimetic exenatide improved glycemic control and reduced body weight in patients
with type 2 diabetes inadequately controlled with metformin ± a sulfonylurea. We assessed postprandial
β-cell function by mathematical modeling, independent of confounding effects from ...
Cited by 18 - Related articles - BL Direct - All 3 versions

[CITATION] Characterization of b-cell function impairment in first-degree relatives of type 2 …


A Mari, A Gastaldelli, A Natali, T … - American …, 2005 - [Bethesda, Md.] American …
Cited by 5 - Related articles

[CITATION] Restoration of an acute insulin response to glucose (AIRg) in drug-naive patients …


DA D'Alessio, CE Watson, YL He, M Ligueros-Saylan, … - Diabetes, 2006
Cited by 8 - Related articles


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