- ►diabetesjournals.org S Shadid, MD Jensen - Diabetes Care, 2003 - Am Diabetes Assoc OBJECTIVE—Insulin resistance is associated with visceral adiposity, and interventions that reduce
this depot, eg, diet and exercise, improve insulin resistance. Thiazolidinediones (TZDs) also
improve insulin action but paradoxically increase total fat mass, perhaps through ... Cited by 73 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org MB Davidson - Diabetes Care, 2003 - Am Diabetes Assoc The clinical definition of the Insulin Resistance or Metabolic Syndrome is shown in Table 1. Subjects
who fulfill these criteria are at increased risk for cardiovascular disease (CVD). The criteria of
the National Cholesterol Education Program are more clinically relevant because those ... Cited by 15 - Related articles - BL Direct - All 5 versions
SR Smith, L de Jonge, J Volaufova, Y Li, H Xie, GA … - Metabolism, 2005 - Elsevier We performed a randomized, double-blind, placebo-controlled trial in 48 men and women with
type 2 diabetes who had not previously received treatment with TZDs. Patients were treated for
24 weeks with 45 mg/d of pioglitazone or a matching placebo. Body composition was ... Cited by 71 - Related articles - All 9 versions
A Basu, MD Jensen, F McCann, D Mukhopadhyay, … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—Pioglitazone increased (P < 0.001 from baseline) total body water (+2.4 ± 0.5 l) accounting
for 75% of the total weight gain (+3.1 ± 2.0 kg) but did not alter vascular endothelial growth factor
concentrations. Total abdominal (−32.2 ± 19 cm 2 ) and visceral fat area (−16.1 ± 8 cm 2 ) ... Cited by 55 - Related articles - BL Direct - All 6 versions
JG Kang, CY Park, SH Ihm, HJ Yoo, H Park, EJ Rhee, … - Metabolism, 2009 - Elsevier Treatment with thiazolidinediones (TZDs) improves glucose homeostasis by increasing insulin
sensitivity, but it also leads to weight gain. Our hypothesis was that, in individual adipose
depots, there is depot specificity for lipid storage and energy expenditure genes after TZD ... Related articles - All 2 versions
- ►diabetesjournals.org K Winkler, T Konrad, S Füllert, I Friedrich, R Destani … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—At baseline, dense LDLs were elevated (apolipoprotein [apo]B in LDL-5 plus
LDL-6 >250 mg/l) in 63% of all patients. Sixteen weeks of treatment with pioglitazone did not
significantly change triglycerides, total, LDL, and HDL cholesterol. However, pioglitazone ... Cited by 91 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org GA Rosito, JM Massaro, U Hoffmann, FL Ruberg, AA … - Circulation, 2008 - Am Heart Assoc From the Cardiac MR CT PET Program, Department of Radiology (GAR, UH, AAM), and the Cardiology
Division (CJO), Massachusetts General Hospital, Harvard Medical School, Boston; Federal Foundation
School of Medical Sciences of Porto Alegre (GAR), Porto Alegre, Rio Grande do Sul, ... Cited by 25 - Related articles - All 8 versions
- ►endojournals.org S Shadid, CDA Stehouwer, MD Jensen - Journal of Clinical …, 2006 - Endocrine Soc Results: Diet/exercise reduced body fat and visceral fat and improved insulin sensitivity
parameters; pioglitazone improved insulin sensitivity to a similar degree but increased body
fat. Adiponectin increased more after pioglitazone (4770 ± 487 vs. 8351 ± 693.6 ng/ml, P ... Cited by 26 - Related articles - BL Direct - All 5 versions
M Brochu, A Tchernof, AN Turner, PA Ades, ET … - Metabolism, 2003 - Elsevier It is presently unclear how much visceral adipose tissue (VAT) loss is needed to induce favorable
metabolic changes. Cross-sectional studies have proposed that a threshold level of VAT exceeding
110 cm 2 in women induces deleterious changes in the metabolic profile. It is presently ... Cited by 29 - Related articles - BL Direct - All 7 versions
- ►endojournals.org Y Miyazaki, A Mahankali, M Matsuda, S … - Journal of Clinical …, 2002 - Endocrine Soc We examined the effect of pioglitazone on abdominal fat distribution to elucidate the mechanisms
via which pioglitazone improves insulin resistance in patients with type 2 diabetes mellitus. Thirteen
type 2 diabetic patients (nine men and four women; age, 52 ± 3 yr; body mass index, 29.0 ... Cited by 340 - Related articles - BL Direct - All 8 versions
