A Kubaszek, J Pihlajamäki, P Karhapää, I … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—The 121Q allele (genotypes K121Q and Q121Q) compared with the K121K genotype
was related to higher fasting insulin levels (group I: 69.6 ± 45.6 vs. 51.9 ± 28.4 pmol/l [mean ±
SD], P = 0.050; group II: 66.6 ± 38.8 vs. 53.8 ± 26.6 pmol/l, P = 0.009). In group I, subjects ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Frittitta, R Baratta, D Spampinato, R Di Paola, … - Journal of Clinical …, 2001 - Endocrine Soc PC-1 is a membrane glycoprotein that impairs insulin receptor function. Its K121Q polymorphism
is a genetic determinant of insulin resistance. We investigated whether the PC-1 gene modulates
insulin sensitivity independently of weight status (ie both in nonobese and obese ... Cited by 37 - Related articles - BL Direct - All 5 versions
JL González-Sánchez, MT Martínez-Larrad, C … - Obesity, 2003 - nature.com Research Methods and Procedures: The subjects of the study were 293 nonrelated adults
(44.7% men and 55.3% women) ages 35 to 64 years randomly chosen from a nationwide
population-based survey on obesity and related conditions, including insulin resistance ... Cited by 30 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] SK Rasmussen, SA Urhammer, A Pizzuti, SM Echwald, … - Diabetes, 2000 - Am Diabetes Assoc The human plasma-cell membrane differentiation anti- gen-1 (PC-1) has been shown to inhibit
insulin receptor tyrosine kinase activity. Recently, a K121Q polymor- phism in the human
PC-1 gene was found in a Sicilian population and was shown to be strongly associated ... Cited by 67 - Related articles - BL Direct - All 4 versions
HF Gu, P Almgren, E Lindholm, L Frittttta, A … - DIABETES-NEW …, 2000 - Am Diabetes Assoc We studied whether there is an association between the single nucleotide polymorphism
c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the metabolic syn- drome in
case-control and intrafamily association studies in 922 subjects from Finland and ... Cited by 93 - Related articles - BL Direct - All 4 versions
BV Costanzo, V Trischitta, R Di Paola, D Spampinato, A … - Diabetes, 2001 - Am Diabetes Assoc When overexpressed, the membrane glycoprotein PC-1 may play a role in human insulin resistance
through the inhibition of insulin receptor (IR) autophosphorylation. A PC-1 variant (K 121 Q, with
lysine 121 replaced by glutamine) is also associated with whole-body insulin resistance ... Cited by 76 - Related articles - BL Direct - All 5 versions
- ►endojournals.org K Hamaguchi, H Terao, Y Kusuda, T Yamashita, … - Journal of Clinical …, 2004 - Endocrine Soc The human glycoprotein PC-1 codon Q121 allele has been correlated with insulin
resistance, but not with type 2 diabetes or obesity. We investigated the prevalence of PC-1 Q121
in the Dominican Republic population (755 subjects studied) and whether this variant is ... Cited by 37 - Related articles - BL Direct - All 5 versions
G Endler, C Mannhalter, H Sunder-Plassmann, M … - Journal of molecular …, 2002 - Springer Abstract Elevated plasma cell membrane glycoprotein 1 (PC-1) expression and the frequent
PC-1 K121Q poly- morphism have recently been associated with insulin re- sistance. Since insulin
resistance represents an important risk factor for atherosclerotic vascular disease and ... Cited by 28 - Related articles - BL Direct - All 4 versions
A Pizzuti, L Frittitta, A Argiolas, R Baratta, ID … - DIABETES-NEW …, 1999 - Am Diabetes Assoc The genes responsible for insulin resistance are poorly defined. Plasma cell differentiation antigen
(PC-1) gly- coprotein inhibits insulin receptor signaling and is associated with insulin
resistance. We describe here a novel polymorphism in exon 4 of the PC-1 gene (K121Q) ... Cited by 147 - Related articles - BL Direct - All 5 versions
- ►tokushima-u.ac.jp [PDF] P Keshavarz, H Inoue, Y Sakamoto, K Kunika, T … - Journal of Human …, 2006 - Springer Abstract Ecto-nucleotide pyrophosphatase/phosphodi- esterase 1 (ENPP1, also known as
PC-1) inhibits insulin signal transduction pathway(s). Previous studies have demonstrated the
K121Q variant of the ENPP1 gene to have a significant functional role in determining sus- ... Cited by 29 - Related articles - BL Direct - All 9 versions
