- ►diabetesjournals.org RR Henry, SRD Mudaliar, WC Howland III, N Chu, … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Inhaled insulin showed area under the curve (AUC) (0–360 min) values that were
significantly greater for healthy subjects than for asthmatic subjects (P = 0.013), whereas no difference
was observed for maximum concentration (C max ) in the two groups. A greater reduction ... Cited by 98 - Related articles - BL Direct - All 5 versions
A Himmelmann, J Jendle, A Mellén, AH Petersen, … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Pharmacokinetic results for evaluable subjects were derived from serum insulin
profiles. The amount of insulin absorbed during the first 6 h after dosing (area under the exogenous
serum insulin curve from 0 to 6 h [AUC (0–6 h) ]) was significantly greater in smokers ... Cited by 100 - Related articles - BL Direct - All 5 versions
A McElduff, LE Mather, PC Kam, P … - British journal of clinical …, 2005 - pubmedcentral.nih.gov Normally healthy adult men (n = 11) and women (n = 9) received a single dose of inhaled human
insulin, equivalent to ~6 IU subcutaneous, using the AERx® insulin Diabetes Management System
(iDMS), during and following recovery from an URTI. The first dose was administered with ... Cited by 35 - Related articles - All 6 versions
K Hermansen, T Ronnemaa, AH Petersen, S Bellaire, … - Diabetes Care, 2004 - 万方数据资源系统 OBJECTIVE:-To compare the glycemic control of inhaled insulin via the AERx insulin diabetes
management system (iDMS) with that of subcutaneous (SC) insulin, both combined with NPH
insulin at bedtime, in patients with type 2 diabetes. RESEARCH DESIGNAND METHODS- ... Cited by 79 - Related articles - BL Direct - All 5 versions
GA Brunner, B Balent, M Ellmerer, L Schaupp, A … - Diabetologia, 2001 - Springer In order to optimise insulin treatment, insulin ana- logues for subcutaeous injection have been
designed recently [1]. Substantial efforts have also been direct- ed towards finding alternative
routes for insulin ad- ministration [2]. The AERx insulin Diabetes Man- agement System ( ... Cited by 89 - Related articles - BL Direct - All 4 versions
- ►profil-research.de [PDF] S Steiner, A Pfützner, BR Wilson, O Harzer, … - Experimental and …, 2002 - thieme-connect.com Technosphere TM /Insulin (TI) is a formulation of regular human insulin and Technosphere TM
, a new drug delivery system for pulmonary administration. The formulation is designed for efficient
transport of insulin across the intact respiratory epithelium into the systemic circulation. ... Cited by 71 - Related articles - BL Direct - All 5 versions
RA Gerber, JC Cappelleri, IA Kourides, RA Gelfand - Diabetes Care, 2001 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Subjects with type 1 diabetes participated in a 12-week
open-label trial and were randomized to either an inhaled insulin regimen or a subcutaneous
insulin regimen. Subjects (n = 69) were asked to complete a 15-item self-administered ... Cited by 101 - Related articles - BL Direct - All 8 versions
JC Cappelleri, WT Cefalu, J Rosenstock, IA Kourides, … - Clinical therapeutics, 2002 - Elsevier Methods: This was a 12-week randomized, open-label, parallel-group, controlled trial in patients
with type 2 diabetes. They were randomized to receive either a subcutaneous insulin regimen
(split/mixed insulin with 2 to 3 injections daily) or an inhaled insulin regimen (inhaled ... Cited by 78 - Related articles - All 5 versions
AD Perera, C Kapitza, L Nosek, RS Fishman, DA … - Diabetes Care, 2002 - Am Diabetes Assoc RESULTS—INH showed a bioavailability (0–8 h postdosing) of 16% and biopotency of 13%
relative to SC. Comparison of the CVs (%) for area under the curve for serum insulin and GIR
between INH and SC showed no significant differences between the treatments during ... Cited by 48 - Related articles - BL Direct - All 5 versions
SJ Farr, A McElduff, LE Mather, J Okikawa, … - Diabetes Technology …, 2000 - liebertonline.com Background: Orally inhaled insulin may provide a convenient and effective therapy for pran-
dial glucose control in patients with diabetes. This study evaluated the influence of formu- lation
pH and concentration and different respiratory maneuvers on pharmacokinetic and ... Cited by 48 - Related articles - BL Direct - All 4 versions
