- ►diabetesjournals.org E Örtqvist, E Björk, M Wallensteen, J Ludvigsson, J … - Diabetes Care, 2004 - Am Diabetes Assoc RESULTS—Diazoxide decreased circulating C-peptide concentrations by ∼50%. After cessation of the
treatment, basal and meal-stimulated C-peptide concentrations increased to a maximum at 6 months,
followed by a decline. ... Cited by 30 - Related articles - BL Direct - All 6 versions
M Matsuda, F Kawasaki, Y Mikami, Y Takeuchi, M … - European journal of …, 2002 - Elsevier In this study, we attempted to demonstrate the possibility of rescuing beta-cell exhaustion by
chronic intervention with an ATP-sensitive K + channel opener, diazoxide, which reduces the stress
of insulin secretion, using rats ... Cited by 16 - Related articles - All 4 versions
E Björk, C Berne, O Kämpe, L Wibell, P Oskarsson, FA … - Diabetes, 1996 - Am Diabetes Assoc Twenty islet cell antibody (ICA)-positive patients, aged 19-38 years, with IDDM were randomized at
onset to treatment with either diazoxide, a K+ channel opener that inhibits the release of insulin,
or placebo for 3 months, in ... Cited by 84 - Related articles - BL Direct - All 5 versions
M Guldstrand, V Grill, A Björklund, PE Lins, U … - Diabetes & metabolism, 2002 - cat.inist.fr Objectif: Notre but était de distinguer les effets bénéfiques de la mise au repos des cellules
bêta des autres effets de la correction de l'hyperglycémie. Pour cela nous avons utilisé le
diazoxide qui bloque de façon ... Cited by 40 - Related articles - BL Direct - All 3 versions
K Skak, CF Gotfredsen, D Lundsgaard, JB Hansen, J … - Diabetes, 2004 - Am Diabetes Assoc Treatment with ATP-sensitive K + channel openers (KCOs) leads to inhibition of insulin secretion and
metabolic “rest” in β-cells. It is hypothesized that in type 1 diabetes this may reduce β-cell
death resulting from metabolic ... Cited by 26 - Related articles - BL Direct - All 4 versions
M Dabrowski, T Larsen, FM Ashcroft, J Bondo Hansen, … - Diabetologia, 2003 - Springer Aims/hypothesis. We investigated the pharmacological properties of two novel ATP sensitive potassium
(K ATP ) channel openers, 6-Chloro-3-isopropylamino- 4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide
(NNC 55-0118) and 6-chloro-3-(1- ... Cited by 29 - Related articles - BL Direct - All 3 versions
S Hiramatsu, A Höög, C Möller, V Grill - Metabolism, 2000 - Elsevier Prolonged hyperglycemia desensitizes β cells. A role for hyperglycemia-induced excessive
stimulation can be tested by diazoxide, which inhibits glucose-induced insulin secretion. Using
diazoxide, we have investigated in ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] A Björklund, A Lansner, VE Grill - Diabetes, 2000 - Am Diabetes Assoc Chronic hyperglycemia desensitizes ß-cells to glucose. To further define the mechanisms behind
desensitiza- tion and the role of overstimulation, we tested human pancreatic islets for the effects
of long-term elevated glucose levels on cytoplasmic free Ca2+ concentration ([Ca2+]i) ... Cited by 55 - Related articles - BL Direct - All 4 versions
RD Carr, CL Brand, TB Bodvarsdottir, JB Hansen, J … - Diabetes, 2003 - Am Diabetes Assoc A novel potassium channel opener compound, NN414, selective for the SUR1/Kir6.2 subtype of the
ATP-sensitive potassium channel, was used to examine the effect of reducing β-cell workload in the
male Vancouver diabetic fatty (VDF) ... Cited by 30 - Related articles - BL Direct - All 4 versions
E Qvigstad, M Kollind, V Grill - Diabetic Medicine, 2004 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 6 - Related articles - BL Direct - All 5 versions
