- ►diabetesjournals.org KR Tuttle, GL Bakris, RD Toto, JB McGill, K Hu, PW … - Diabetes Care, 2005 - Am Diabetes Assoc RESULTS—At baseline, urinary ACR was 764 ± 427 mg/g (means ± SD), and eGFR was 70 ± 24 ml/min
per 1.73 m 2 . Systolic and diastolic blood pressures were 135 ± 14 and 75 ± 9 mmHg, respectively.
HbA 1c was 8.0 ± 1.2%. After 1 ... Cited by 96 - Related articles - BL Direct - All 5 versions
AI Vinik, V Bril, P Kempler, WJ Litchy, S Tesfaye, KL … - Clinical therapeutics, 2005 - Elsevier Patients were enrolled in a multinational, randomized, Phase II, double-blind, placebo-controlled
parallel-group trial comparing 32 mg/d or 64 mg/d RBX with placebo for 1 year. DPN was identified by
abnormal measurable vibration ... Cited by 45 - Related articles - All 3 versions
- ►iovs.org LP Aiello, A Clermont, V Arora, MD Davis, MJ Sheetz, … - … ophthalmology & visual …, 2006 - ARVO RESULTS. Twenty-nine persons aged 18 to 65 years with type 1 or 2 diabetes were evaluated. The only
treatment-emergent adverse event with a statistically significant difference among treatment groups
was abdominal pain, which was more ... Cited by 65 - Related articles - BL Direct - All 5 versions
JB McGill, GL King, PH Berg, KL Price, KA … - Expert Opin. Drug …, 2006 - informahealthcare.com The aim of this manuscript is to report the safety profile of patients treated with ruboxistaurin
mesylate (RBX; LY333531), a selective protein kinase C-β (PKC-β) inhibitor, for up to 4 years.
Data from patients with diabetes ... Cited by 22 - Related articles - BL Direct - All 5 versions
- ►asnjournals.org DJ Kelly, A Chanty, RM Gow, Y Zhang, RE … - Journal of the American …, 2005 - Am Soc Nephrol Tubulointerstitial macrophage accumulation is an important marker of prognosis that correlates
closely with declining renal function in a range of human and experimental diseases, including
diabetic nephropathy. These ... Cited by 47 - Related articles - All 6 versions
- ►asnjournals.org KR Tuttle, JB McGill, DJ Haney, TE Lin, PW … - Clinical Journal of the …, 2007 - Am Soc Nephrol Background: A pilot study showed that ruboxistaurin (RBX), a protein kinase C ß inhibitor,
significantly decreased albuminuria and stabilized kidney function over 1 yr in patients who had
diabetic nephropathy and persistent ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org DJ Kelly, Y Zhang, C Hepper, RM Gow, K Jaworski, BE … - Diabetes, 2003 - Am Diabetes Assoc In addition to hyperglycemia, hypertension and the renin-angiotensin system have been consistently
implicated in the pathogenesis of diabetic nephropathy. Each of these pathogenetic factors may
induce changes in cellular function ... Cited by 149 - Related articles - BL Direct - All 5 versions
- ►fasebj.org D KOYA, M HANEDA, H NAKAGAWA, K ISSHIKI, H … - The FASEB Journal, 2000 - FASEB Activation of protein kinase C (PKC) is implicated as an important mechanism by which diabetes
causes vascular complications. We have recently shown that a PKC ß inhibitor ameliorates not only
early diabetes-induced glomerular ... Cited by 277 - Related articles - BL Direct - All 4 versions
RE Gilbert, SA Kim, KR Tuttle, GL Bakris, RD Toto, … - Diabetes care, 2007 - Am Diabetes Assoc We obtained urine from participants in a prospective, double-blind, placebo-controlled study of the
effects of ruboxistaurin 32 mg/day in patients with diabetic nephropathy (11), in which the effect
on urinary TGF-β was a ... Cited by 12 - Related articles - BL Direct - All 6 versions
