- ►worldsign.in [PDF] - Free from Publisher SL Bowker, SR Majumdar, P Veugelers, JA … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—We identified 10,309 new users of metformin or sulfonylureas with an
average follow-up of 5.4 ± 1.9 years (means ± SD). The mean age for the cohort
was 63.4 ± 13.3 years, and 55% were men. Cancer mortality over follow-up ... Cited by 105 - Related articles - BL Direct - All 8 versions
- ►bmj.com [PDF] JMM Evans, LA Donnelly, AM Emslie-Smith, … - British Medical Journal, 2005 - bmj.com Voluntary surveillance systems are subject to under-reporting. Figures may
underestimate true numbers. Miscategorisation of probable country of infection
by presuming the country with the highest prevalence as the likely country ... Cited by 145 - Related articles - All 12 versions
M Zakikhani, R Dowling, IG Fantus, N … - Cancer Research, 2006 - AACR Metformin (1,1-dimethylbiguanide hydrochloride) is a biguanide commonly used in
the treatment of type 2 diabetes mellitus (1). It is frequently referred to as
an "insulin sensitizer" because in settings of insulin resistance and ... Cited by 75 - Related articles - BL Direct - All 7 versions
M Buzzai, RG Jones, RK Amaravadi, JJ Lum, … - Cancer Research, 2007 - AACR Beyond the reported effects of metformin on insulin-responsive tissues, little
is known about the effects of metformin on other cell types. However, AMPK is a
intracellular fuel sensor that regulates cellular homeostasis in response ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►aacrjournals.org RJO Dowling, M Zakikhani, IG Fantus, M … - Cancer research, 2007 - AACR Metformin is a biguanide drug that is widely used for the treatment of type 2
diabetes (16, 17). The effectiveness of metformin as an antidiabetic drug is
explained by its ability to decrease blood glucose by decreasing hepatic ... Cited by 48 - Related articles - BL Direct - All 4 versions
IB Sahra, K Laurent, A Loubat, S Giorgetti- … - Oncogene, 2008 - nature.com Metformin is a widely used antidiabetic agent, which regulates glucose
homeostasis through inhibition of liver glucose production and an increase in
muscle glucose uptake. Recent studies suggest that metformin may reduce the ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►nih.gov KN Phoenix, F Vumbaca, KP Claffey - Breast cancer research and treatment, 2009 - Springer Abstract Metformin, a first line treatment for type 2 diabetes, has been
implicated as a potential anti-neoplastic agent for breast cancers as well as
other cancers. Metfor- min is known to work in part through the activation ... Cited by 17 - Related articles - All 3 versions
VN Anisimov, LM Berstein, PA Egormin, TS … - Experimental gerontology, 2005 - Elsevier Studies in mammals have led to the suggestion that hyperglycemia and
hyperinsulinemia are important factors both in aging and in the development of
cancer. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules ... Cited by 36 - Related articles - All 3 versions
RJ Shaw, KA Lamia, D Vasquez, SH Koo, N … - Science, 2005 - sciencemag.org The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine
kinase, LKB1, which phosphorylates and activates AMPK [adenosine monophosphate
(AMP)–activated protein kinase]. The deletion of LKB1 in the liver of ... Cited by 300 - Related articles - BL Direct - All 17 versions
MB Schneider, H Matsuzaki, J Haorah, A … - Gastroenterology, 2001 - Elsevier Our previous study suggested that the known promotional effect of a high fat
diet, which in hamsters induces peripheral insulin resistance, is related to a
compensatory proliferation of islet cells. The present study was to examine ... Cited by 80 - Related articles - BL Direct - All 8 versions
