K Ekberg, T Brismar, BL Johansson, P Lindström, L … - Diabetes Care, 2007 - Am Diabetes Assoc RESULTS—The age of the 139 patients who completed the protocol was 44.2 ± 0.6 (mean ±
SE) years and their duration of diabetes was 30.6 ± 0.8 years. Clinical neurological impairment
(NIA) (score >7 points) of the lower extremities was present in 86% of the patients at ... Cited by 37 - Related articles - BL Direct - All 5 versions
L Luzi, G Zerbini, A Caumo - Diabetologia, 2007 - Springer Page 1. FOR DEBATE C-peptide: a redundant relative of insulin? L. Luzi & G. Zerbini & A. Caumo
Received: 19 June 2006 /Accepted: 24 October 2006 / Published online: 16 January 2007 #
Springer-Verlag 2007 Keywords C-peptide . Diabetic complications . Type 1 diabetes ... Cited by 11 - Related articles - BL Direct - All 4 versions
M Henriksson, E Nordling, E Melles, J Shafqat, M … - Cellular and Molecular …, 2005 - Springer Received 2 May 2005; received after revision 9 June 2005; accepted 13 June 2005 ...
Abstract. Proinsulin C-peptide influences a number of physiological parameters in addition to
its well-established role in the parent proinsulin molecule. It is of interest as a candidate ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►asnjournals.org NM Al-Rasheed, GB Willars, NJ Brunskill - Journal of the American …, 2006 - Am Soc Nephrol Cell loss by apoptosis occurs in renal injury such as diabetic nephropathy. TNF- is a cytokine
that induces apoptosis and has been implicated in the pathogenesis of diabetic
nephropathy. The aim was to investigate whether C-peptide or insulin could modulate ... Cited by 19 - Related articles - BL Direct - All 11 versions
Z Zhong, A Davidescu, I Ehrén, K Ekberg, H Jörnvall, J … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Accumulating evidence in- dicates that replacement of C-peptide in
type 1 diabetes ameliorates nerve and kidney dysfunction, but the molec- ular mechanisms involved
are incompletely understood. C-peptide shows specific binding to a G-protein-coupled ... Cited by 26 - Related articles - All 3 versions
IG Joshua, Q Zhang, JC Falcone, AP … - Journal of cellular …, 2005 - interscience.wiley.com Complications associated with insulin-dependent diabetes mellitus (type-1diabetes) primarily
represent vascular dysfunction that has its origin in the endothelium. While many of the vascular
changes are more accountable in the late stages of type-1diabetes, changes that occur in ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org D Walcher, M Aleksic, V Jerg, V Hombach, A Zieske, S … - Diabetes, 2004 - Am Diabetes Assoc Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin
resistance and early type 2 diabetes, a high-risk population for the development of a diffuse and
extensive pattern of arteriosclerosis. The present study examined the effect of C-peptide ... Cited by 37 - Related articles - BL Direct - All 4 versions
T Wallerath, T Kunt, T Forst, EI Closs, R Lehmann, T … - Nitric Oxide, 2003 - Elsevier There is increasing evidence for biological functions of human C-peptide. Recently, we have
described that proinsulin C-peptide increases nutritive capillary blood flow and restores erythrocyte
deformability in type 1 diabetic patients, whereas it has no such effect in non-diabetic ... Cited by 40 - Related articles - All 4 versions
- ►oxfordjournals.org B Samnegard, SH Jacobson, G Jaremko, BL … - Nephrology Dialysis …, 2005 - ERA-EDTA Methods. The effects of C-peptide or placebo on glomerular volume, mesangial expansion, glomerular
basement membrane thickness, albuminuria and glomerular filtration rate (GFR) were studied
in three groups of rats: a non-diabetic group (N, n = 9) and two groups that, during 8 ... Cited by 19 - Related articles - All 4 versions
- ►physiology.org MJ Stevens, W Zhang, F Li, AAF … - American Journal of …, 2004 - Am Physiological Soc Oxidative stress and neurovascular dysfunction have emerged as contributing factors to the development
of experimental diabetic neuropathy (EDN) in streptozotocin-diabetic rodents. Additionally, depletion
of C-peptide has been implicated in the pathogenesis of EDN, but the mechanisms of ... Cited by 33 - Related articles - All 4 versions
