- ►nih.gov C Götting, J Kuhn, K Kleesiek - Diabetes care, 2008 - Am Diabetes Assoc OBJECTIVE—Proteoglycan metabolism is altered in diabetic patients. The
xylosyltransferases (XTs) are the initial and rate-limiting enzymes in the
biosynthesis of the glycosaminoglycan chains in proteoglycans. Here, we ... Cited by 1 - Related articles - All 4 versions
JC Casanova, J Kuhn, K Kleesiek, C Götting - Biochemical and Biophysical Research …, 2007 - Elsevier Human xylosyltransferase II (EC 2.4.2.26, XT-II) represents an isoform of
xylosyltransferase I (XT-I). Recently, we and others provided first evidence
that XT-II is capable of initiating the biosynthesis of glycosaminoglycan ... Cited by 5 - Related articles - All 4 versions
- ►pnas.org E Condac, R Silasi-Mansat, S Kosanke, T … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences The basic biochemical mechanisms underlying many heritable human polycystic
diseases are unknown despite evidence that most cases are caused by mutations in
members of several protein families, the most prominent being the ... Cited by 6 - Related articles - BL Direct - All 9 versions
S Gharagozlian, J Borrebæk, T Henriksen, TK … - European Journal of Nutrition, 2006 - Springer The Diabetes Control and Complications Trail [1] that chronic hyperglycemia is
the main contributing factor to the pathological changes observed in persons
with diabetes type I. Elevated levels of glucose in the cir- culation will ... Cited by 7 - Related articles - BL Direct - All 3 versions
S Schön, C Prante, C Bahr, L Tarnow, J Kuhn, … - Diabetes care, 2006 - Am Diabetes Assoc OBJECTIVE—Xylosyltransferase I (XT-I) is the chain-initiating enzyme in the
biosynthesis of proteoglycans in basement membranes. It catalyzes the transfer
of xylose to selected serine residues in the core protein. The XYLT-II gene ... Cited by 6 - Related articles - BL Direct - All 5 versions
JC Casanova, C Roch, J Kuhn, K Kleesiek, C … - Biochemical and Biophysical Research …, 2009 - Elsevier Human xylosyltransferases I and II (XylT-I, XylT-II) are key enzymes in
glycosaminoglycan biosynthesis. Knowledge about the in vivo molecular weight,
oligomeric state or turnover number are essential characteristics which ... Cited by 1 - Related articles - All 2 versions
E Condac, GL Dale, D Bender-Neal, B … - Glycobiology, 2009 - Soc Glycobiology Circulating glycosyltransferases including xylosyltransferases I (XylT1) and II
(XylT2) are potential serum biomarkers for various diseases. Understanding what
influences the serum activity of these enzymes as well as the sources of ... Related articles - All 3 versions
- ►ahajournals.org CA Vogl-Willis, IJ Edwards - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc Methods and Results— SEM was prepared from human bovine aortic endothelial
cells (HAECs) and bovine aortic endothelial cells (BAECs) cultured in the
presence of low (5 mmol/L) or high (30 mmol/L) glucose for 3 to 5 days. ... Cited by 11 - Related articles - BL Direct - All 8 versions
C Götting, J Kuhn, K Kleesiek - Cellular and molecular life sciences, 2007 - Springer Abstract. The xylosyltransferases I and II (XT-I, XT- II, EC 2.4.2.26) catalyze
the transfer of xylose from UDP-xylose to selected serine residues in the
proteo- glycan core protein, which is the initial and rate- limiting step ... Cited by 22 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org U Pfeil, KW Wenzel - Glycobiology, 2000 - Soc Glycobiology UDP-xylosyltransferase (UDP-D-xylose:proteoglycan core protein
ß-D-xylosyltransferase EC 2.4.2.26) initiates the formation of chondroitin
sulfate in the course of proteoglycan biosynthesis. The enzyme catalyzes ... Cited by 12 - Related articles - BL Direct - All 4 versions
