- ►diabetesjournals.org SE Kahn, B Zinman, JM Lachin, SM Haffner, WH … - Diabetes Care, 2008 - Am Diabetes Assoc RESULTS—In men, fracture rates did not differ between treatment groups. In women, at least
one fracture was reported with rosiglitazone in 60 patients (9.3% of patients, 2.74 per 100
patient-years), metformin in 30 patients (5.1%, 1.54 per 100 patient-years), and glyburide ... Cited by 37 - Related articles - BL Direct - All 19 versions
D Yu, MA Heise, RP Aftring, G Viberti - Diabetes Care, 2008 - Am Diabetes Assoc OBJECTIVE — The purpose of this study was to examine possible factors associated with the
increased risk of fractures observed with rosiglitazone in A Diabetes Outcome Progression Trial
(ADOPT). ... RESEARCH DESIGN AND METHODS — Data from the 1,840 women and ... Related articles
- ►ammom.com.mx [PDF] C Meier, ME Kraenzlin, M Bodmer, SS Jick, H … - Archives of Internal …, 2008 - Am Med Assoc Methods This study examines the association between the use of thiazolidinediones or other
oral antidiabetic drugs and the risk of fracture. This nested case-control analysis uses the UK
General Practice Research Database, including case patients with fracture aged 30 to 89 ... Cited by 71 - Related articles - BL Direct - All 8 versions
S Yaturu, B Bryant, SK Jain - Diabetes Care, 2007 - Am Diabetes Assoc Case-control studies of patients with fractures have found that subjects with diabetes have at
least a twofold higher risk of fracture than subjects without diabetes (1), with an increased risk
of hip, humerus, and foot fractures in elderly diabetic subjects (2–4). Risk factors that ... Cited by 61 - Related articles - BL Direct - All 7 versions
A Grey - Osteoporosis International, 2008 - Springer Abstract Thiazolidinediones (TZDs) are agonists of the peroxisome proliferator-activated receptor
gamma (PPARγ) nuclear transcription factor. Two members of this drug class, rosiglitazone and
pioglitazone, are commonly used in the management of type II diabetes mellitus, and play ... Cited by 39 - Related articles - BL Direct - All 3 versions
AV Schwartz, DE Sellmeyer - Expert Opin. Drug Saf., 2008 - informahealthcare.com Rosiglitazone and pioglitazone are associated with increased fracture risk in women, and, for
rosiglitazone, more rapid bone loss. Negative skeletal effects of these thiazolidinediones
(TZDs) have also been observed in animal and in vitro models. A central mechanism of ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] E Erdmann, B Charbonnel, RG Wilcox, AM Skene, … - Diabetes Care, 2007 - Am Diabetes Assoc Page 1. Pioglitazone Use and Heart Failure in Patients with Type 2 Diabetes and Preexisting
Cardiovascular Disease: Data from the PROactive Study (PROactive 08) Erland Erdmann,
MD, FESC, FACC 1 ; Bernard Charbonnel, MD 2 ;Robert G Wilcox, ... Cited by 28 - Related articles - BL Direct - All 6 versions
- ►endojournals.org OP Lazarenko, SO Rzonca, WR Hogue, FL Swain, LJ … - Endocrinology, 2007 - Endocrine Soc Peroxisome proliferator-activated receptor- (PPAR ) regulates both glucose metabolism and
bone mass. Recent evidence suggests that the therapeutic modulation of PPAR activity with
antidiabetic thiazolidinediones elicits unwanted effects on bone. In this study, the effects ... Cited by 60 - Related articles - BL Direct - All 8 versions
- ►oxfordjournals.org DJ Betteridge, RA DeFronzo, RJ Chilton - European Heart Journal, 2008 - Eur Soc Cardiology The PROspective pioglitAzone Clinical Trial In macroVascular Events (PROactive) remains the
only completed cardiovascular (CV) outcomes study with a thiazolidinedione. It has provided
valuable information on the impact of pioglitazone on CV outcomes in a high-risk ... Cited by 12 - Related articles - BL Direct - All 10 versions
AV Schwartz, DE Sellmeyer - Diabetes Care, 2007 - Am Diabetes Assoc In December 2006, the ADOPT trial reported a higher risk of fractures in diabetic women randomized
to rosiglitazone than in women randomized to metformin or glyburide (3). The ADOPT trial followed
4,360 (42% women) participants with a mean age of 57 years for a median of 4 years. ... Cited by 11 - Related articles - All 5 versions
