- ►diabetesjournals.org [PDF] A Brandstätter, S Kiechl, B Kollerits, SC Hunt, IM … - Diabetes care, 2008 - Am Diabetes Assoc OBJECTIVE — High serum uric acid levels lead to gout and have been reported to be asso-
ciated with an increased risk of hypertension, obesity, metabolic syndrome, type 2 diabetes, and
cardiovascular disease. Recently, the putative fructose transporter SLC2A9 was reported ... Cited by 10 - Related articles - All 6 versions
- ►jbc.org N Anzai, K Ichida, P Jutabha, T Kimura, E Babu, CJ … - Journal of Biological …, 2008 - ASBMB Hyperuricemia is a significant factor in a variety of diseases, including gout and cardiovascular
diseases. Although renal excretion largely determines plasma urate concentration, the molecular
mechanism of renal urate handling remains elusive. Previously, we identified a major ... Cited by 12 - Related articles - All 3 versions
AB PhD, MD Stefan Kiechl, BK MSc, SCH PhD, IMH … - Am Diabetes Assoc 1 Division of Genetic Epidemiology; Department of Medical Genetics, Molecular and Clinical
Pharmacology; Innsbruck Medical University, Innsbruck, Austria 2 Department of Neurology,
Innsbruck Medical University, Innsbruck, Austria 3 Cardiovascular Genetics Division, ... Related articles
- ►iranianra.org [PDF] J Chao, R Terkeltaub - Current Rheumatology Reports, 2009 - Springer Allopurinol, the first-line drug for serum urate–low- ering therapy in gout, is approved by the US
Food and Drug Administration for a dose up to 800 mg/d and is available as a low-cost generic
drug. However, the vast majority of allopurinol prescriptions are for doses ≤ 300 mg/d, ... Cited by 3 - Related articles - All 3 versions
D Bannasch, N Safra, A Young, N Karmi, RS … - PLoS …, 2008 - pubmedcentral.nih.gov Allantoin is the end product of purine catabolism in all mammals except humans, great apes,
and one breed of dog, the Dalmatian. Humans and Dalmatian dogs produce uric acid during
purine degradation, which leads to elevated levels of uric acid in blood and urine and can ... Cited by 4 - Related articles - All 6 versions
S Li, S Sanna, A Maschio, F Busonero, G Usala, … - PLoS …, 2007 - pubmedcentral.nih.gov High serum uric acid levels elevate pro-inflammatory–state gout crystal arthropathy and place
individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the
genetically isolated Sardinian population identified variants associated with serum uric ... Cited by 42 - Related articles - All 11 versions
K Stark, W Reinhard, K Neureuther, S Wiedmann, K … - PLoS ONE, 2008 - pubmedcentral.nih.gov Serum uric acid (UA) levels have recently been shown to be genetically influenced by common
polymorphisms in the GLUT9 gene in two genome-wide association analyses of Italian and British
populations. Elevated serum UA levels are often found in conjunction with the metabolic ... Cited by 14 - Related articles - All 7 versions
A Döring, C Gieger, D Mehta, H Gohlke, H Prokisch, S … - Nature genetics, 2008 - nature.com Serum uric acid concentrations are correlated with gout and clinical entities such as cardiovascular
disease and diabetes. In the genome-wide association study KORA (Kooperative Gesundheitsforschung
in der Region Augsburg) F3 500K (n = 1,644), the most significant SNPs associated with ... Cited by 53 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org MPT Le, M Shafiu, W Mu, RJ Johnson - Nephrology Dialysis Transplantation, 2008 - ERA-EDTA SLC2A9 was recently cloned and identified as a member of the SLC2A gene family of hexose
facilitative transporters, where its main physiological role was assumed to be in the transport
of glucose and fructose. However, new findings have unearthed a novel role for SLC2A9 ( ... Cited by 6 - Related articles - All 5 versions
V Vitart, I Rudan, C Hayward, NK Gray, J Floyd, CNA … - Nature genetics, 2008 - nature.com Uric acid is the end product of purine metabolism in humans and great apes, which have lost
hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500
M) compared with other mammals (3–120 M) 1 . About 70% of daily urate disposal occurs ... Cited by 70 - Related articles - BL Direct - All 5 versions
