- Free from Publisher MY Donath, DM Schumann, M Faulenbach, H … - Diabetes Care, 2008 - Am Diabetes Assoc Inflammation is defined as the local response to tissue injury. It is
characterized by immune cell invasion and local release of cytokines and
chemokines and is sometimes accompanied by functional or structural damage ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►endojournals.org NS Sauter, FT Schulthess, R Galasso, LW … - Endocrinology, 2008 - Endocrine Soc Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes.
Elevated cytokines impair β-cell function and survival. A recent clinical trial
shows that blocking IL-1β signaling by IL-1 receptor antagonist (IL-1Ra) ... Cited by 18 - Related articles - BL Direct - All 4 versions
JW Kim, SH Ko, JH Cho, C Sun, OK Hong, SH … - Frontiers in bioscience: a journal and virtual library, 2008 - ncbi.nlm.nih.gov Recent morphologic analyses of human pancreases strongly suggest that a
decreased beta-cell mass is observed from the early stages of diabetes and is
caused by accelerated apoptosis of the beta-cells. In this article, we ... Cited by 4 - Related articles
MY Donath, JA Ehses - Pancreatic Beta Cell in Health and Disease, 2007 - Springer Summary. A decrease in both mass and secretory function of insulin produc- ing
beta cells contribute to the pathophysiology of type 1 and type 2 diabetes. In
this chapter, we review the evidence that glucose, inflammation, dyslipid- ... Related articles - All 2 versions
- ►shouxi.net MY Donath, JA Ehses, K Maedler, DM … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to
the pathophysiology of type 2 diabetes. Opinions diverge regarding the relative
contribution of a decrease in β-cell mass versus an intrinsic defect in ... Cited by 85 - Related articles - BL Direct - All 6 versions
JA Ehses, G Lacraz, MH Giroix, F Schmidlin, … - Proceedings of the National Academy of Sciences, 2009 - National Acad Sciences Recent studies suggest an inflammatory process, characterized by local
cytokine/chemokine production and immune cell infiltration, regulates islet
dysfunction and insulin resistance in type 2 diabetes. However, the factor ... Cited by 2 - Related articles - All 6 versions
JA Ehses, S Calderari, JC Irminger, P … - Current Immunology Reviews, 2007 - ingentaconnect.com 1 CNRS UMR 7059, Université Paris 7-D Diderot, Paris, France 2 Department of
Internal Medicine, Division of Endocrinology & Diabetes, University Hospital of
Zürich and Center for Integrative Human Physiology, Zürich, Switzerland 3 ... Cited by 4 - Related articles - BL Direct
- ►endojournals.org M Boni-Schnetzler, J Thorne, G Parnaud, L … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Results: Gene array analysis of RNA from β-cells of individuals with T2DM
revealed increased expression of IL-1β mRNA. Real-time PCR confirmed increased
IL-1β expression in six of 10 T2DM samples, with minimal or no expression ... Cited by 6 - Related articles - All 4 versions
- ►pnas.org H Ellingsgaard, JA Ehses, EB Hammar, L Van … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Interleukin-6 (IL-6) is systemically elevated in obesity and is a predictive
factor to develop type 2 diabetes. Pancreatic islet pathology in type 2 diabetes
is characterized by reduced β-cell function and mass, an increased ... Cited by 6 - Related articles - All 8 versions
- ►numesi.com [PDF] B Portha, G Lacraz, M Kergoat, F Homo- … - Molecular and Cellular Endocrinology, 2009 - Elsevier Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of type 2 diabetes (T2D) mellitus. Nowadays, the debate focuses on the
possible mechanisms responsible for abnormal islet microenvironment, ... Cited by 6 - Related articles - All 3 versions
