J Scott, PL Poffenbarger - Diabetes, 1979 - Am Diabetes Assoc This study was designed to focus on the genetic control of tolbutamide
dispositon in humans and to provide insight into the potential for high accrued
blood levels in individuals receiving fixed dosage regimens. Tolbutamide ... Cited by 104 - Related articles - All 3 versions
JO Miners, LMH Wing, DJ Birkett - Internal Medicine Journal, 1985 - interscience.wiley.com The metabolism of debrisoquine and theophylline has been studied in a healthy
male who was identified as a slow hydroxylator of tolbutamide. Tolbutamide
clearance in this subject was threefold lower than the lowest tolbutamide ... Cited by 26 - Related articles - All 2 versions
- ►pharmacogeneticsandgenomics.com [PDF] ME Veronese, JO Miners, DLP Rees, DJ … - Pharmacogenetics and Genomics, 1993 - journals.lww.com Pharmacogenetics of tolbutamide metabolism 87 that these protein(s) play a major
role in the human liver metabolism of tolbutamide (Veronese et al, 1991, 1993),
as has been suggested by other workers (Brian et al, 1989; Relling et al, ... Cited by 39 - Related articles - All 3 versions
- ►nih.gov [PDF] MA Page, JS Boutagy, GM Shenfield - British journal of clinical pharmacology, 1991 - pubmedcentral.nih.gov 1 Six subjects participated in a detailed pharmacokinetic study of tolbutamide
(pilot study). Using parameters based on these data, sixty-three non-diabetic
volunteers underwent a simple screening test designed to identify slow ... Cited by 17 - Related articles - All 5 versions
RC Thomas, GJ Ikeda - Journal of Medicinal Chemistry, 1966 - pubs.acs.org The Metabolic Fate of Tolbutamide in Man and in the Rat ... RICHARD C. THOMAS
AND GEORGE J. IKEDA ... Biochemical Research Division, The Upjohn Company,
Kalamzoo, Michigan ... Tritium-labeled tolbutamide was found to be ... Cited by 66 - Related articles - All 2 versions
RS Kidd, AB Straughn, MC Meyer, J Blaisdell, … - Pharmacogenetics and Genomics, 1999 - journals.lww.com Pharmacogenetics 1999, 9:71-80 Original article Pharmacokinetics of
chlorpheniramine, phenytoin, glipizide and nifedipine in an individual
homozygous for the CYP2C9*3 allele Robert S. Kidda, Arthur B. Straughnb, ... Cited by 124 - Related articles - BL Direct - All 3 versions
P Vermeij, MD Ferrari, OJS Buruma, H … - Clinical Pharmacology & Therapeutics, 1988 - nature.com The mode of inheritance of insufficient phenytoin p-hydroxylation was studied in
the family of a patient who had previously suffered from a phenytoin
intoxication caused by insufficient metabolism of this drug. This family ... Cited by 22 - Related articles - All 3 versions
ME Veronese, JO Miners, D Randles, D Gregov … - Clinical Pharmacology & Therapeutics, 1990 - nature.com The present study has validated kinetically a convenient method to measure
tolbutamide hydroxylation capacity in human beings by use of urinary metabolic
ratios. The known in vivo and in vitro inhibitory properties of ... Cited by 73 - Related articles - All 4 versions
JB McCrea, A Cribb, T Rushmore, B Osborne, … - Clinical pharmacology and therapeutics, 1999 - cat.inist.fr Phenotypic and genotypic investigations of a healthy volunteer deficient in
the conversion of losartan to its active metabolite E-3174. ... Cited by 57 - Related articles - BL Direct - All 4 versions
T Inaba - Pharmacology & therapeutics, 1990 - ncbi.nlm.nih.gov The metabolism of phenytoin via 4'-hydroxylation is subject to large
inter-individual variability. The ratio of drug/metabolite (DPH/HPPH) in plasma
and the reverse ratio for urine, metabolite/drug (HPPH/DPH), have been ... Cited by 34 - Related articles - All 2 versions
