YT Kim, C Steinberg - Diabetes, 1984 - Am Diabetes Assoc Repeated low doses of streptozotocin (STZ, 40 mg/kg body wt) gradually induce hyperglycemia
in mice after a latent period of 5-7 days. The ability of STZ to induce hyperglycemia varies in
different mouse strains. Repeated low doses of STZ fail to induce diabetes in ... Cited by 41 - Related articles - All 4 versions
SG Paik, ML Blue, N Fleischer, S Shin - Diabetes, 1982 - Am Diabetes Assoc In genetically susceptible strains of mice, repeated injections of a subdiabetogenic dose of streptozotocin
induces the development of progressive insulin-dependent hyperglycemia. We showed previously
that host T-cell functions play an obligatory etiologic role in this experimental disease by ... Cited by 19 - Related articles - All 4 versions
- ►pnas.org [PDF] SG Paik, N Fleischer, SI Shin - Proceedings of the National …, 1980 - National Acad Sciences Page 1. Proc. Natl. Acad. Sci. USA Vol. 77, No. 10, pp. 6129-6133, October 1980 Medical
Sciences Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of
streptozotocin: Obligatory role of cell-mediated autoimmune processes ... Cited by 74 - Related articles - All 7 versions
ML Blue, SI Shin - Diabetes, 1984 - Am Diabetes Assoc Multiple subdiabetogenic doses of streptozotocin induce an insulin-dependent progressive hyperglycemia
in genetically susceptible strains of mice. We have shown previously that T-cell-dependent autoimmune
mechanisms play an obligatory role in this model of diabetogenesis by demonstrating that ... Cited by 9 - Related articles - All 4 versions
M Nakamura, S Nagafuchi, K Yamaguchi, R Takaki - Diabetes, 1984 - Am Diabetes Assoc This article is concerned with the role of thymic immunity in the development of diabetes experimentally
induced by multiple injections of subdiabetogenic doses of streptozocin (STZ). Euthymic +/+,
+/nu, and athymic nu/nu mice of CD-1 and BALB/cAJcl origin were studied. Daily ... Cited by 19 - Related articles - All 4 versions
M Oschilewski, E Schwab, U Kiesel, U Opitz, K … - Immunology …, 1986 - ncbi.nlm.nih.gov Multiple injections of low doses of streptozotocin induce an experimental diabetes in mice. We
have analyzed in two inbred strains whether the development of hyperglycaemia can be influenced
by administration of macrophage-toxic silica particles or by a monoclonal antibody to Thy- ... Cited by 37 - Related articles
- ►pnas.org [PDF] AA Rossini, AA Like, WL Chick, MC … - Proceedings of the …, 1977 - National Acad Sciences Page 1. Proc. NatI. Acad. Sci. USA Vol. 74, No. 6, pp. 2485-2489, June 1977 Cell Biology
Studies of streptozotocin-induced insulitis and diabetes (pancreatic beta cells/islets of
Langerhans/alloxan diabetes/type C virus induction/cell-mediated reaction) ... Cited by 95 - Related articles - All 7 versions
- ►pnas.org [PDF] EH Leiter - Proceedings of the National Academy of Sciences, 1982 - National Acad Sciences ABSTRACT Insulin-dependent diabetes induced in suscepti- ble strains ofmice by multiple,
low-dose streptozotocin treatment has been proposed to entail a thymus-dependent, autoimmune
destruction ofbeta cells. In this study, thymectomized and genet- ically athymic mice have ... Cited by 47 - Related articles - All 7 versions
AA Rossini, RM Williams, MC Appel, AA Like - 1978 - nature.com STREPTOZOTOCIN (SZ) is a broad-spectrum antibiotic with oncolytic, oncogenic and diabetogenic
properties 1−4 . To produce diabetes in experimental animals, SZ is administered as a single
bolus, injected either intravenously (iv) or intraperitoneally (ip). Within 72 h, selective ... Cited by 79 - Related articles - All 3 versions
