MW Sadelain, HY Qin, J Lauzon, B Singh - Diabetes, 1990 - Am Diabetes Assoc The nonobese diabetic (NOD) mouse is an excellent model of insulin-dependent (type I) human
diabetes mellitus. We report that a single injection of complete Freund's adjuvant (CFA) given
at an early age (5 wk) prevented the appearance of diabetes and greatly increased the ... Cited by 163 - Related articles - All 3 versions
MF McInerney, SB Pek, DW Thomas - Diabetes, 1991 - Am Diabetes Assoc In studies of immune cell defects in autoimmune diabetes mellitus, we observed that complete
Freund's adjuvant (CFA) prevented the onset of diabetes when injected into 8- to 10-wk-old prediabetic
nonobese diabetic (NOD) mice. The prevalence of the onset of diabetes in the ... Cited by 72 - Related articles - All 4 versions
M Harada, Y Kishimoto, S Makino - Diabetes research and clinical …, 1990 - ncbi.nlm.nih.gov A single intravenous injection of 0.25-1 mg of live BCG organisms at approximately 10 weeks
of age produced a potent suppression of insulitis and overt diabetes in non-obese,
diabetes-prone (NOD) female mice. Injection of 1 mg of BCG into younger mice, aged 5 ... Cited by 68 - Related articles
HY Qin, MW Sadelain, C Hitchon, J Lauzon, … - The Journal of …, 1993 - Am Assoc Immnol Page 1. 0022-1 767/93/1505-2072$02.00/0 The Journal of Immunology Copyright 0 1993
by The American Association of Immunologists Vol 150, 2072-2080, No. 5, March 1, 1993
Printed in USA Complete Freund's Adjuvant-Induced T Cells ... Cited by 118 - Related articles - BL Direct - All 3 versions
N Shehadeh, F Calcinaro, BJ Bradley, I Bruchim, P … - Lancet, 1994 - ncbi.nlm.nih.gov 1: Lancet. 1994 Mar 19;343(8899):706-7. Erratum in: Lancet. 2006 Apr 15;367(9518):1240.
Bruchlim, I [corrected to Bruchim, I]. Comment in: Lancet. 1994 Mar 19;343(8899):684-5. Effect
of adjuvant therapy on development of diabetes in mouse and man. ... Cited by 115 - Related articles - BL Direct - All 4 versions
MW Sadelain, HY Qin, W Sumoski, N Parfrey, B … - Journal of …, 1990 - ncbi.nlm.nih.gov The BB rat spontaneously develops an insulin-dependent diabetes mellitus (IDDM) that closely
resembles this disease in man. The pathogenesis involves autoimmune destruction of pancreatic
islet beta-cells. In the present study, a single intraperitoneal injection of complete ... Cited by 47 - Related articles
D Ulaeto, PE Lacy, DM Kipnis, O … - Proc Natl Acad Sci …, 1992 - National Acad Sciences ABSTRACT Three experimental manipulations showed the suppressive effect of injection of
complete Freund's adju- vant (CFA) in the diabetic state of nonobese diabetic (NOD) mice. (i)
Diabetes was inhibited in young NOD mice injected with the adjuvant. (ii) Recurrence of ... Cited by 44 - Related articles - All 9 versions
T Wang, B Singh, GL Warnock, RV Rajotte - Diabetes, 1992 - Am Diabetes Assoc Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing
cells in the islets of Langerhans. One possible cure is by transplanting the islet cells;
however, transplanted islets, even between identical twins, are subject to autoimmune ... Cited by 66 - Related articles - All 4 versions
NN Shehadeh, F LaRosa, KJ Lafferty - Journal of Autoimmunity, 1993 - Elsevier The destructive insulitis that develops in disease-prone NOD mice is characterized by a high
frequency of IFN-γ-producing cells in the lesion. Complete Freund's adjuvant (CFA) challenge
of young, disease-prone animals inhibits the development of diabetes but does not alter ... Cited by 135 - Related articles - BL Direct - All 3 versions
T Toyota, J Satoh, K Oya, S Shintani, T Okano - Diabetes, 1986 - Am Diabetes Assoc OK-432 (a streptococcal preparation) has been widely used for cancer immunotherapy in
Japan. It is the most potent immunomodulator in activating both macrophages and killer T cells
and in increasing interleukin 2 production. Two KE (Klinische Einheit, clinical unit) of ... Cited by 52 - Related articles - All 4 versions
