GJ Biessels, A Kamal, GM Ramakers, IJ Urban, BM … - Diabetes, 1996 - Am Diabetes Assoc Moderate impairment of learning and memory has been recognized as a complication of diabetes. The
present study examined behavioral and electrophysiological measures of cerebral function in
streptozotocin (STZ)-induced ... Cited by 148 - Related articles - BL Direct - All 6 versions
GJ Biessels, A Kamal, IJA Urban, BM Spruijt, DW … - Brain research, 1998 - Elsevier Streptozotocin-diabetic rats express deficits in water maze learning and hippocampal synaptic
plasticity. The present study examined whether these deficits could be prevented and/or reversed
with insulin treatment. In ... Cited by 132 - Related articles - All 6 versions
A Kamal, GJ Biessels, IJA Urban, WH Gispen - Neuroscience, 1999 - Elsevier Streptozotocin-diabetic rats, an animal model for diabetes mellitus, show learning deficits and
impaired long-term potentiation in the CA1-field of the hippocampus. The present study aimed to
further characterize the effects of ... Cited by 68 - Related articles - BL Direct - All 4 versions
C Chabot, G Massicotte, M Milot, F Trudeau, J Gagné - Brain research, 1997 - Elsevier -aspartate (NMDA) subtype of glutamate receptors, suggesting that NMDA receptor function remained
intact in STZ-treated slices. At the biochemical level, the capacity of calcium to increase [ 3
H](RS)-α-amino-3-hydroxy-5- ... Cited by 62 - Related articles - All 5 versions
JF Flood, AD Mooradian, JE Morley - Diabetes, 1990 - Am Diabetes Assoc We demonstrated that mice with streptozocin-induced diabetes mellitus have normal acquisition for
relatively simple tasks but show problems in learning more complex tasks such as shuttle box
avoidance. Enhanced learning ... Cited by 78 - Related articles - All 5 versions
A Kamal, GJ Biessels, SEJ Duis, WH Gispen - Diabetologia, 2000 - Springer Aims/hypothesis. Diabetes mellitus leads to function- al and structural changes in the brain which
appear to be most pronounced in the elderly. Because the pathogenesis of brain ageing and that of
diabetic complications show close ... Cited by 83 - Related articles - BL Direct - All 3 versions
WH Gispen, GJ Biessels - Trends in Neurosciences, 2000 - Elsevier Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia,
particularly in the elderly. These deficits are paralleled by neurophysiological and structural
changes in the brain. In animal ... Cited by 242 - Related articles - All 10 versions
GJ Biessels, AC Kappelle, B Bravenboer, DW Erkelens, … - Diabetologia, 1994 - Springer Summary Diabetes mellitus is a common metabolic disorder associated with chronic complications such
as nephropathy, angiopathy, retinopathy and peri- pheral neuropathy. Diabetes is not often
considered to have deleterious ... Cited by 154 - Related articles - BL Direct - All 3 versions
ZG Li, W Zhang, G Grunberger, AAF Sima - Brain research, 2002 - Elsevier Duration-related cognitive impairment is an increasingly recognized complication of type 1 diabetes.
To explore potential underlying mechanisms, we examined hippocampal abnormalities in the
spontaneously type 1 diabetic BB/W ... Cited by 102 - Related articles - All 4 versions
M Di Luca, L Ruts, F Gardoni, F Cattabeni, GJ Biessels, … - Diabetologia, 1999 - Springer Diabetes mellitus is known to be associated with neu- rological complications in both the peripheral
and the central nervous system. Manifestations of cerebral disorders in diabetic patients include
alterations in neurotransmission, ... Cited by 49 - Related articles - BL Direct - All 4 versions
