G Perseghin, S Ghosh, K Gerow, GI Shulman - Diabetes, 1997 - Am Diabetes Assoc First-degree relatives of NIDDM patients have an approximately 40% lifetime risk of developing
diabetes, and insulin resistance is the best predictor. However, insulin resistance is altered by
many other factors, including age, diet, exercise, and medications. To investigate the ... Cited by 191 - Related articles - BL Direct - All 5 versions
G Gulli, E Ferrannini, M Stern, S Haffner, RA DeFronzo - Diabetes, 1992 - Am Diabetes Assoc NIDDM patients with overt fasting hyperglycemia are characterized by multiple defects involving
both insulin secretion and insulin action. At this point of the natural history of NIDDM,
however, it is difficult to establish which defects are primary and which are acquired ... Cited by 192 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] I Vauhkonen, L Niskanen, E Vanninen, S … - Journal of Clinical …, 1998 - pubmedcentral.nih.gov No studies are available that have compared early defects in glucose metabolism in the offspring
of insulin-deficient and insulin-resistant probands with non–insulin-dependent dia- betes mellitus
(NIDDM). To investigate this issue, we evalu- ated insulin secretion capacity with oral and ... Cited by 122 - Related articles - BL Direct - All 6 versions
W Pimenta, M Korytkowski, A Mitrakou, T Jenssen, H … - Jama, 1995 - Am Med Assoc OBJECTIVE--To test the hypothesis that insulin resistance precedes impaired insulin secretion
in individuals genetically predisposed to non-insulin-dependent diabetes mellitus (NIDDM).
DESIGN--Case-control study. SETTING--Outpatient facility of clinical research center. ... Cited by 258 - Related articles - BL Direct - All 4 versions
M Krssak, K Falk Petersen, A Dresner, L DiPietro, SM … - Diabetologia, 1999 - Springer Skeletal muscle insulin resistance is a common fea- ture of obesity, dyslipidaemia and arterial
hyperten- sion, and it is an important predisposing factor for Type II (non-insulin-dependent)
diabetes mellitus and premature cardiovascular disease [1]. Evidence has been provided ... Cited by 558 - Related articles - BL Direct - All 6 versions
M Roden, M Krssak, H Stingl, S Gruber, A … - DIABETES-NEW …, 1999 - Am Diabetes Assoc The initial effects of free fatty acids (FFAs) on glu- cose transport/phosphorylation were studied
in seven healthy men in the presence of elevated (1.44 ± 0.16 mmol/l), basal (0.35 ± 0.06
mmol/l), and low (<0.01 mmol/l; control) plasma FFA concentrations (P < 0.05 between all ... Cited by 114 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] G Perseghin, P Scifo, F De Cobelli, E Pagliato, A … - Diabetes, 1999 - Am Diabetes Assoc Determinant of in Vivo Insulin Resistance in Humans ... A 1 H - 1 3 C Nuclear Magnetic Resonance
Spectroscopy ... Assessment in Offspring of Type 2 Diabetic Parents ... Gianluca Perseghin,
Paola Scifo, Francesco De Cobelli, Emanuela Pagliato, Alberto Battezzati, Cinzia ... Cited by 436 - Related articles - BL Direct - All 4 versions
- ►nih.gov A Dresner, D Laurent, M Marcucci, ME … - Journal of Clinical …, 1999 - Am Soc Clin Investig To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human
skeletal muscle, glycogen, glucose-6-phosphate, and intracellular glucose concentrations were
measured using carbon-13 and phosphorous-31 nuclear magnetic resonance ... Cited by 664 - Related articles - BL Direct - All 9 versions
JH Warram, BC Martin, AS Krolewski, JS … - Annals of internal …, 1990 - Am Coll Physicians Add to CiteULike Add to Complore Add to Connotea Add to Del.icio.us Add to Digg Add to Facebook
Add to Reddit Add to Technorati Add to Twitter What's this? ... Objective: To determine whether
insulin resistance or insulin deficiency is primary in the pathogenesis of type II diabetes. Cited by 649 - Related articles - All 4 versions
