- ►diabetesjournals.org [PDF] GT Nepom, WW Kwok - Diabetes, 1998 - Am Diabetes Assoc Autoimmune diabetes is the clinical end point for a sequential cascade of
immunologic events that occur in a genetically susceptible individual.
Structural and functional analysis of the HLA class II susceptibility genes ... Cited by 128 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org DV Serreze, TM Holl, MP Marron, RT Graser, … - The Journal of Immunology, 2004 - Am Assoc Immnol Development of autoreactive CD4 T cells contributing to type 1 diabetes (T1D) in
both humans and nonobese diabetic (NOD) mice is either promoted or dominantly
inhibited by particular MHC class II variants. In addition, it is now clear ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org RA Ettinger, AW Liu, GT Nepom, WW Kwok - The Journal of Immunology, 1998 - Am Assoc Immnol HLA-DQ alleles are closely associated with susceptibility and resistance to
insulin-dependent diabetes mellitus (IDDM) but the immunologic mechanisms
involved are not understood. Structural studies of the IDDM-susceptible ... Cited by 44 - Related articles - All 3 versions
GT Nepom - Diabetes, 1990 - Am Diabetes Assoc Our understanding of the role of HLA genes associated with insulin-dependent
diabetes mellitus (IDDM) is in disarray, despite recent improvements in the
definition of specific alleles and haplotypes. Some genes are highly ... Cited by 138 - Related articles - All 3 versions
M Zamani, JJ Cassiman - American journal of medical genetics, 1998 - interscience.wiley.com Several publications have shown that certain alleles at the HLA-DRB1, -DQA1, and
-DQB1 loci are associated with insulin-dependent diabetes mellitus (IDDM). Many
of these studies have claimed that HLA-DQ 1 Arg52 and DQ 1 Asp57 showed the ... Cited by 27 - Related articles - BL Direct - All 4 versions
JX she - Immunology today, 1996 - Elsevier The HLA class II region encodes the strongest genetic contribution to
insulin-dependent diabetes mellitus (IDDM); however, the complex HLA
associations with IDDM are not yet fully understood. Here, Jin-Xiong She ... Cited by 260 - Related articles - BL Direct - All 3 versions
T Lund, L O'Reilly, P Hutchings, O Kanagawa, …, 1990 - nature.com INSULIN-dependent diabetes mellitus (IDDM) is a disease with an autoimmune
aetiology. The inbred non-obese diabetic (NOD) mouse strain provides a good
animal model of the human disease 1 and genetic analysis suggests that, as ... Cited by 217 - Related articles - All 5 versions
- ►rupress.org D Schmidt, J Verdaguer, N Averill, P … - Journal of Experimental Medicine, 1997 - jem.rupress.org Certain major histocompatibility complex (MHC) class II haplotypes encode
elements providing either susceptibility or dominant resistance to the
development of spontaneous autoimmune diseases via mechanisms that remain ... Cited by 147 - Related articles - BL Direct - All 5 versions
DE Undlien, T Friede, HG Rammensee, G Joner, … - Diabetes, 1997 - Am Diabetes Assoc Recent studies have shown that the risk conferred by the high-risk
DQA1*03-DQB1*0302 (DQ8) haplotype is modified by the DRB1*04 allele that is also
carried by this haplotype. However, many of these studies suffer from lack ... Cited by 132 - Related articles - BL Direct - All 4 versions
RM Slattery, L Kjer-Nielsen, J Allison, B …, 1990 - nature.com THE non-obese diabetic (NOD) mouse develops insulin-dependent diabetes mellitus
(IDDM) with mononuclear cell infiltration of the islets of Langerhans and
selective destruction of the insulin-producing -cells, as in humans 1 . ... Cited by 142 - Related articles - All 4 versions
