- ►diabetesjournals.org [PDF] C Ploix, I Bergerot, A Durand, C Czerkinsky, J … - Diabetes, 1999 - Am Diabetes Assoc Restoration of peripheral tolerance to target autoanti- gens during autoimmune diseases has
met with several limitations because of the limited efficacy of this approach in an already immune
host. To optimize the induction of tolerance, we have shown that feeding insulin ... Cited by 58 - Related articles - BL Direct - All 5 versions
… , V Apostolopolous, D Homann, T Wolfe, A … - Clinical and …, 2003 - pubmedcentral.nih.gov Our earlier investigations have demonstrated a critical difference in the efficacy of orally administered
porcine compared to human or mouse insulin (no effect) in preventing type I diabetes in two distinct
experimental models. Based on these findings one has to assume that certain insulins ... Cited by 22 - Related articles - BL Direct - All 5 versions
C Aspord, C Thivolet - Clinical and Experimental Immunology, 2002 - pubmedcentral.nih.gov Nasal administration of beta cell-derived auto-antigens has been reported to suppress the development
of autoimmune diabetes. We investigated the tolerogenic effects of insulin conjugated to the
B subunit of cholera toxin (CTB). Nasal administration of 1 µg of CTB-insulin significantly ... Cited by 16 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org D Homann, T Dyrberg, J Petersen, M … - The Journal of …, 1999 - Am Assoc Immnol Oral administration of self-Ags can dampen or prevent autoimmune processes by induction of
bystander suppression. Based on encouraging results from experiments in nonobese diabetic
(NOD) mice, clinical trials have been initiated in type 1 diabetes using human insulin as ... Cited by 51 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] I Bergerot, GA Arreaza, MJ Cameron, MD Burdick, RM … - Diabetes, 1999 - Am Diabetes Assoc The mechanism of protection from type 1 diabetes con- ferred by regulatory T-cells induced by
oral insulin treatment of NOD mice is not well understood. We demonstrate that oral insulin feeding
of NOD mice induces the function of insulin B-chain reactive CD4+ regulatory T-cells, ... Cited by 46 - Related articles - BL Direct - All 6 versions
I Bergerot, C Ploix, J Petersen, V Moulin, … - Proceedings of the …, 1997 - National Acad Sciences Mucosally induced immunological tolerance is an attractive strategy for preventing or treating
illnesses resulting from untoward inflammatory immune reactions against self- or
non-self-antigens. Oral administration of relevant autoantigens and allergens has been ... Cited by 156 - Related articles - BL Direct - All 8 versions
P Pozzilli, D Pitocco, N Visalli, MG Cavallo, R Buzzetti, … - Diabetologia, 2000 - Springer The use of insulin, given either subcutaneously or orally, in subjects at risk for Type I diabetes
has been recently introduced in the Diabetes Prevention Trial of Type I diabetes (DPT-1)
trial, a large multinational trial in the United States, with the aim of preventing the ... Cited by 90 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org JB Sun, BG Xiao, M Lindblad, BL Li, H Link, C … - International …, 2000 - Jpn Soc Immunol The efficacy and mechanism of immunosuppression against experimental autoimmune encephalomyelitis
(EAE) by oral low-dose administration of myelin basic protein (MBP) conjugated to cholera toxin
B subunit (CTB) were investigated in Lewis rats immunized with MBP together with ... Cited by 39 - Related articles - BL Direct - All 3 versions
A Tarkowski, JB Sun, R Holmdahl, J Holmgren, … - Arthritis Care & … - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 36 - Related articles - BL Direct - All 3 versions
S Bregenholt, M Wang, T Wolfe, A Hughes … - Scandinavian …, 2003 - interscience.wiley.com When conjugated to various proteins, the nontoxic B-chain of cholera toxin (CTB) significantly
increases the ability of these proteins to induce immunological tolerance after oral
administration. Here, we investigated if a nonconjugated form of CTB enhances the ... Cited by 26 - Related articles - BL Direct - All 5 versions
