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Beta-cell maturation leads to in vitro sensitivity to cytotoxins

- diabetesjournals.org [PDF] 
K Nielsen, AE Karlsen, M Deckert, OD Madsen … - Diabetes, 1999 - Am Diabetes Assoc
Pancreatic ß-cells are more sensitive to several toxins (eg, streptozotocin,
alloxan, cytokines) than the other three endocrine cell types in the islets of
Langer- hans. Cytokine-induced free radicals in ß-cells may be involved in ...
Cited by 49 - Related articles - BL Direct - All 4 versions

and Jørn Nerup


K Nielsen, AE Karlsen, M Deckert, OD … - DIABETES, 1999 - Am Diabetes Assoc
Pancreatic -cells are more sensitive to several toxins (eg, streptozotocin,
alloxan, cytokines) than the other three endocrine cell types in the islets of
Langer- hans. Cytokine-induced free radicals in -cells may be involved in ...
Related articles

Interferon-{gamma} induces interleukin-1 converting enzyme expression in pancreatic islets …

- endojournals.org
AE Karlsen, D Pavlovic, K Nielsen, J Jensen, … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc
Whereas nitric oxide (NO) production is associated with the toxic effect of
cytokines on rodent pancreatic ß-cells, cytokine-induced apoptosis in human
islets may occur independently of NO. The cysteine protease interleukin ...
Cited by 56 - Related articles - BL Direct - All 4 versions

Proteome analysis of interleukin-1β–induced changes in protein expression in rat islets of …

- diabetesjournals.org
PM Larsen, SJ Fey, MR Larsen, A Nawrocki, HU … - Diabetes, 2001 - Am Diabetes Assoc
The intracellular molecular events involved in the β-cell death process are
complex but poorly understood. Cytokines, eg, interleukin (IL)-1β, may play a
crucial role in inducing this process. Protein synthesis is necessary for ...
Cited by 60 - Related articles - BL Direct - All 4 versions

Massive parallel gene expression profiling of RINm5Fpancreatic islet beta-cells stimulated …


K Rieneck, B LF, K Josefsen, K Buschard, M … - Apmis, 2000 - ingentaconnect.com
Page 1. APMIS 108: 855–72, 2000 Copyright C APMIS 2000 Printed in Denmark .
All rights reserved ISSN 0903-4641 Massive parallel ...
Cited by 31 - Related articles - BL Direct - All 4 versions

Cytokine-or chemically derived nitric oxide alters the expression of proteins detected by two …


NE John, HU Andersen, SJ Fey, PM Larsen, P … - DIABETES-NEW YORK-, 2000 - Am Diabetes Assoc
Interleukin-1 (IL-1 ) treatment of neonatal rat islets for 24 h induces changes
in the expression of 105 of 2,200 proteins, as determined previously by
two-dimen- sional (2D) gel electrophoresis. Nitric oxide (NO) has been ...
Cited by 40 - Related articles - BL Direct - All 4 versions

Islet protein expression changes during diabetes development in islet syngrafts in BB-DP rats …


UB Christensen, PM Larsen, SJ Fey, HU … - Autoimmunity, 2000 - informahealthcare.com
J ' 2000 OPA (Ovcrseas Publishers A~socist~on) N V. Published by license under
the Harwood Academic Publishers Imprint. part of The Gordon and Breach
Publishing Group Printed in Maliiysia. ... BB-DP Rats and during Rejection of
Cited by 24 - Related articles - BL Direct - All 6 versions

Interleukin-1 induced changes in the protein expression of rat islets: A computerized …


HU Andersen, SJ Fey, PM Larsen, A Nawrocki, … - Electrophoresis, 1997 - interscience.wiley.com
Insulin-dependent diabetes mellitus is caused by an autoimmune destruction of
the -cells in the islets of Langerhans. The cytokine interleukin 1 inhibits
insulin release and is selectively cytotoxic to -cells in isolated ...
Cited by 34 - Related articles - BL Direct - All 3 versions

On the pathogenesis of IDDM


J Nerup, T Mandrap-Poulsen, S Helqvist, HU … - Diabetologia, 1994 - Springer
Dr. Nerup obtained his MD from the University of Copenhagen in 1964. He
completed postgraduate education in Copenhagen, Denmark, the Karolinska
Hospital, Stockholm, Sweden, and the Royal Hammersmith Hospital, London, ...
Cited by 102 - Related articles - BL Direct - All 4 versions

Proteome analysis--A novel approach to understand the pathogenesis of Type 1 diabetes …


AE Karlsen, T Sparre, K Nielsen, J Nerup, F … - Disease markers, 2001 - IOS Press
Type 1 (insulin-dependent) diabetes mellitus (T1DM) is as- sociated with a
specific destruction of the insulin-producing beta-cells in the islets of
Langerhans. Several factors, eg genetic, environmental and immunologial, ...
Cited by 14 - Related articles - BL Direct - All 4 versions


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