- ►diabetesjournals.org [PDF] H Kaneto, Y Kajimoto, J Miyagawa, T Matsuoka, Y … - Diabetes, 1999 - Am Diabetes Assoc Oxidative stress is produced under diabetic conditions and possibly causes various forms of
tissue damage in patients with diabetes. The aim of this study was to examine the involvement
of oxidative stress in the pro- gression of pancreatic ß-cell dysfunction in type 2 dia- betes ... Cited by 267 - Related articles - BL Direct - All 7 versions
- ►pnas.org Y Tanaka, CE Gleason, POT Tran, JS … - Proceedings of the …, 1999 - National Acad Sciences Chronic exposure of pancreatic islets to supraphysiologic concentrations of glucose causes adverse
alterations in β cell function, a phenomenon termed glucose toxicity and one that may play a
secondary pathogenic role in type 2 diabetes. However, no mechanism of action has ... Cited by 206 - Related articles - BL Direct - All 10 versions
PPPCA Glucose - DIABETES, 1999 - Am Diabetes Assoc Oxidative stress is produced under diabetic conditions and possibly causes various forms of
tissue damage in patients with diabetes. The aim of this study was to examine the involvement
of oxidative stress in the pro- gression of pancreatic -cell dysfunction in type 2 dia- betes ... Related articles
Y Tanaka, POT Tran, J Harmon, RP … - Proceedings of the …, 2002 - National Acad Sciences Antioxidant drugs have been reported to protect pancreatic islets from the adverse effects of chronic
exposure to supraphysiological glucose concentrations. However, glucose has not been shown
to increase intracellular oxidant load in islets, nor have the effects of increasing or ... Cited by 115 - Related articles - BL Direct - All 10 versions
Y Ihara, S Toyokuni, K Uchida, H Odaka, T Tanaka, H … - Diabetes, 1999 - Am Diabetes Assoc Reactive oxygen species are involved in a diversity of biological phenomena such as
inflammation, carcinogenesis, aging, and atherosclerosis. We and other investigators have shown
that the level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker for oxidative stress, is ... Cited by 185 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] T Matsuoka, Y Kajimoto, H Watada, H … - Journal of Clinical …, 1997 - pubmedcentral.nih.gov Prolonged poor glycemic control in non–insulin-dependent diabetes mellitus patients often leads
to a decline in insulin secretion from pancreatic cells, accompanied by a de- crease in the insulin
content of the cells. As a step toward elucidating the pathophysiological background of ... Cited by 145 - Related articles - BL Direct - All 13 versions
M Tiedge, S Lortz, J Drinkgern, S Lenzen - Diabetes, 1997 - Am Diabetes Assoc Antioxidant enzyme expression was determined in rat pancreatic islets and RINm5F insulin-producing
cells on the level of mRNA, protein, and enzyme activity in comparison with 11 other rat
tissues. Although superoxide dismutase expression was in the range of 30% of the liver ... Cited by 333 - Related articles - BL Direct - All 6 versions
Y Ihara, Y Yamada, S Toyokuni, K Miyawaki, N Ban, T … - FEBS letters, 2000 - Elsevier We have shown recently that oxidative stress by chronic hyperglycemia damages the pancreatic
β-cells of GK rats, a model of non-obese type 2 diabetes, which may worsen diabetic condition
and suggested the administration of antioxidants as a supportive therapy. To determine if ... Cited by 59 - Related articles - All 6 versions
H Kaneto, G Xu, N Fujii, S Kim, S Bonner-Weir, GC … - Journal of Biological …, 2002 - ASBMB Oxidative stress, which is found in pancreatic β-cells in the diabetic state, suppresses insulin
gene transcription and secretion, but the signaling pathways involved in the β-cell dysfunction
induced by oxidative stress remain unknown. In this study, subjecting rat islets to ... Cited by 133 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] RP Robertson, HJ Zhang, KL Pyzdrowski, … - Journal of Clinical …, 1992 - pubmedcentral.nih.gov Glucose toxicity of the pancreatic beta cell is considered to play a secondary role in the pathogenesis
of type II diabetes melli- tus. To gain insights into possible mechanisms of action of glu- cose
toxicity, we designed studies to assess whether the loss of insulin secretion associated ... Cited by 126 - Related articles - All 6 versions
