- ►diabetesjournals.org [PDF] A Bektas, JH Warram, MF White, AS Krolewski … - Diabetes, 1999 - Am Diabetes Assoc We investigated whether variability at the insulin receptor substrate (IRS)-2
locus plays a role in the eti- ology of early-onset autosomal dominant type 2
dia- betes. By means of radiation hybrid mapping, we placed the human IRS-2 ... Cited by 29 - Related articles - BL Direct - All 6 versions
D Bernal, K Almind, L Yenush, M Ayoub, Y … - DIABETES-NEW YORK-, 1998 - Am Diabetes Assoc Type 2 diabetes is a complex disease characterized by insulin resistance in
target tissues and a reduced capacity to produce compensatory levels of insulin
in pancreatic -cells (1). Not surpris- ingly, a single molecular defect ... Cited by 67 - Related articles - BL Direct - All 7 versions
- ►whitelabs.org [PDF] K Almind, SK Frederiksen, D Bernal, T … - Diabetologia, 1999 - Springer The importance of the insulin receptor substrate-2 (IRS-2) has recently been
investigated in mice in which the homozygous deficiency of IRS-2 causes a Type
II (non-insulin-dependent) diabetes-like pheno- type due to both insulin ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►whitelabs.org [PDF] K Kalidas, J Wasson, B Glaser, JM Meyer, LJ … - Diabetologia, 1998 - Springer The insulin receptor substrates are intracellular pro- teins that are
phosphorylated by the insulin receptor and mediate the actions of insulin.
Insulin receptor substrate (IRS)-1 has been well characterized and shown to ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org S Mammarella, F Romano, A Di Valerio, B … - Human Molecular Genetics, 2000 - Oxford Univ Press The insulin receptor substrate-2 (IRS-2) is a major insulin signalling molecule.
IRS-2 inactivation in mice induces a form of diabetes characterized by
peripheral insulin resistance and reduced beta cell mass. We tested the ... Cited by 61 - Related articles - BL Direct - All 4 versions
RJ Sigal, A Doria, JH Warram, AS Krolewski - Journal of Clinical Endocrinology & Metabolism, 1996 - Endocrine Soc Page 1. OOZl-972x/96/$03.00/0 Journal of Clinical Endocrinology and Metabolism
Copyright 0 1996 by The Endocrine Society Vol. 81, No. 4 Printed in USA ... Cited by 56 - Related articles - All 5 versions
- ►nih.gov O Porzio, M Federici, ML Hribal, D Lauro, D … - Journal of Clinical Investigation, 1999 - Am Soc Clin Investig Recent studies have identified several polymorphisms in the human insulin
receptor substrate-1 (IRS-1) gene. The most prevalent IRS-1 variant, a Gly→Arg
change at the codon 972, has been reported to be increased in prevalence ... Cited by 116 - Related articles - BL Direct - All 8 versions
R Yoshimura, E Araki, S Ura, M Todaka, K … - Diabetes, 1997 - Am Diabetes Assoc Insulin receptor substrate-1 (IRS-1) is one of the major substrates of insulin
receptor tyrosine kinase and mediates various insulin signals downstream. In
this study, we have examined the impact of three natural IRS-1 mutations ... Cited by 39 - Related articles - BL Direct - All 4 versions
H Mori, M Hashiramoto, M Kishimoto, M … - Journal of Clinical Endocrinology & Metabolism, 1995 - Endocrine Soc 0021-972x/95/$03.00/0 Journal of Clinical Endocrinology and Metabolism Copyright
0 1995 by The Endocrine Society ... HIROYUKI MORI, MITSURU HASHIRAMOTO, MIYAKO
KISHIMOTO, AND ... MASATO KASUGA The Second Department of Internal ... Cited by 17 - Related articles - BL Direct - All 4 versions
[CITATION] Molecular scanning of the IRS-1 gene in Japanese patients with non-insulin-dependent …
