G Frühbeck - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc Leptin administration has been shown to increase renal, adrenal, and lumbar sympathetic nerve
activity. H owever, this generalized sympathoexcitatory activity is not always followed by an increase
in arterial pres- sure. The present study tested the hypothesis that lep- tin induces a ... Cited by 220 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] G Lembo, C Vecchione, L Fratta, G Marino, V Trimarco, … - Diabetes, 2000 - Am Diabetes Assoc In this study, we reveal that leptin evokes an acute hypotensive effect in 6-hydroxydopamine
sympathec- tomized rats (response to maximal leptin dose, mean blood pressure: from 92 ± 4
to 78 ± 2 mmHg, P < 0.01). This hemodynamic effect is related to a direct action of the ... Cited by 173 - Related articles - BL Direct - All 4 versions
K Kimura, K Tsuda, A Baba, T Kawabe, S Boh-oka, … - … and Biophysical Research …, 2000 - Elsevier Leptin is a polypeptide, mainly produced in white adipose tissue, and increases sympathetic
nerve activity. A few studies investigated leptin's effect on peripheral vessels. We examined the
vasorelaxant effects of human leptin on rat arteries. Arterial rings were precontracted with ... Cited by 119 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Vecchione, A Maffei, S Colella, A Aretini, R Poulet, G … - Diabetes, 2002 - Am Diabetes Assoc Recent evidence suggests that besides its action on the central nervous system, leptin can modulate
vascular tone through local mechanisms involving nitric oxide (NO) release. In this study, using
a fluorescent probe for direct determination of NO, we demonstrated both in endothelial ... Cited by 163 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org EW Shek, MW Brands, JE Hall - Hypertension, 1998 - Am Heart Assoc Plasma leptin concentration is increased in hypertensive obese humans, but whether leptin contributes
to the increased arterial pressure in obesity is not known. In this study, we tested whether chronic
increases in leptin, to levels comparable to those in obesity, could cause a sustained ... Cited by 483 - Related articles - BL Direct - All 4 versions
JC Dunbar, Y Hu, H Lu - Diabetes, 1997 - Am Diabetes Assoc Obesity and hyperinsulinism are known to be major stimuli of leptin production by adipose
tissue, leading to increased leptin levels in the circulation. It has also been demonstrated that
increased leptin production leads to satiety, possibly by decreasing the levels of ... Cited by 257 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org JL Mitchell, DA Morgan, MLG Correia, AL Mark, WI … - Hypertension, 2001 - Am Heart Assoc Abstract—— Leptin decreases appetite and increases sympathetic nerve activity and arterial
pressure. Recent reports suggest that leptin may also have peripheral vasodilator actions that
would tend to reduce arterial pressure. We tested the hypothesis that the direct vascular ... Cited by 43 - Related articles - BL Direct - All 6 versions
- ►physiology.org [PDF] EK Jackson, P Li - American Journal of Physiology- Renal …, 1997 - Am Physiological Soc Jackson, Edwin K., and Ping Li. Human leptin has natriuretic activity in the rat. Am. J.
Physiol. 272 (Renal Physiol. 41): F333-F338, 1997.-The purpose of this study was to determine
whether leptin influences renal function. Increasing doses (0.3, 1, 3, 10, and 30 ug/min; ... Cited by 113 - Related articles - BL Direct - All 3 versions
- ►physiology.org B Winters, Z Mo, E Brooks-Asplund, S Kim, … - Journal of Applied …, 2000 - Am Physiological Soc Obesity is a major health care problem and is associated with significant cardiovascular
morbidity. Leptin, a neuroendocrine hormone released by adipose tissue, is important in modulating
obesity by signaling satiety and increasing metabolism. Moreover, leptin receptors are ... Cited by 86 - Related articles - BL Direct - All 4 versions
AL Mark, RA Shaffer, MLG Correia, DA Morgan, … - Journal of …, 1999 - journals.lww.com Objective Recent advances in understanding the neuroendocrine pathways regulating
appetite, metabolism and body weight afford an opportunity to explore further the mechanisms
by which obesity in¯uences arterial pressure. ob/ob(Lepob/ Lepob) mice have a mutation ... Cited by 138 - Related articles - BL Direct - All 3 versions
