- ►diabetesjournals.org [PDF] CB Chan, RM MacPhail, L Sheu, MB Wheeler, HY … - Diabetes, 1999 - Am Diabetes Assoc In normal isolated ß-cells, the response to glucose is heterogeneous and characterized by an
increasing num- ber of secretory cells as glucose concentration rises (Pipeleers DG, Kiekens
R, Ling Z, Wilikens A, Schuit F: Physiologic relevance of heterogeneity in the pancreatic ... Cited by 46 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] S Nagamatsu, Y Nakamichi, C Yamamura, S … - Diabetes, 1999 - Am Diabetes Assoc Page 1. DIABETES, VOL. 48, DECEMBER 1999 2367 Decreased Expression of t-SNARE,
Syntaxin 1, and SNAP-25 in Pancreatic ß-Cells Is Involved in Impaired Insulin Secretion From
Diabetic GK Rat Islets Restoration of Decreased t-SNARE Proteins Improves ... Cited by 100 - Related articles - BL Direct - All 5 versions
- ►endojournals.org HY Gaisano, CG Ostenson, L Sheu, MB Wheeler, S … - Endocrinology, 2002 - Endocrine Soc The role of glucotoxicity in dysregulation of islet exocytotic soluble N-ethylmaleimide-sensitive
factor attachment protein receptor (SNARE) complex proteins and insulin response was explored
in the hyperglycemic Goto-Kakizaki (GK) rat. Syntaxin-1A and vesicle-associated ... Cited by 40 - Related articles - BL Direct - All 5 versions
CG Ostenson, H Gaisano, L Sheu, A Tibell, T Bartfai - Diabetes, 2006 - Am Diabetes Assoc Exocytosis of insulin is dependent on the soluble N-ethylmaleimide attachment protein receptor
(SNARE) complex proteins in the B-cells. We assessed insulin release as well as gene and protein
expression of SNARE complex protein in isolated pancreatic islets of type 2 diabetic ... Cited by 49 - Related articles - BL Direct - All 5 versions
MB Wheeler, L Sheu, M Ghai, A Bouquillon, G Grondin, … - Endocrinology, 1996 - Endocrine Soc Page 1. 0013.7227/96/$03 00/o Endocrinology Copyright 0 1996 by The Endocrine
Society Vol. 137. No. 4 Prrnfrd in USA Characterization of SNARE Protein Expression
in p Cell Lines and Pancreatic Islets* MICHAEL B. WHEELER ... Cited by 150 - Related articles - BL Direct - All 3 versions
EA Pasyk, Y Kang, X Huang, N Cui, L Sheu, HY … - Journal of Biological …, 2004 - ASBMB ATP-sensitive potassium (K ATP ) channels in neuron and neuroendocrine cells consist of a
pore-forming Kir6.2 and regulatory sulfonylurea receptor (SUR1) subunits, which are regulated
by ATP and ADP. SNARE protein syntaxin 1A (Syn-1A) is known to mediate exocytic ... Cited by 32 - Related articles - BL Direct - All 4 versions
YM Leung, Y Kang, X Gao, F Xia, H Xie, L Sheu, S … - Journal of Biological …, 2003 - ASBMB Voltage-gated K + (Kv) 2.1 is the dominant Kv channel that controls membrane repolarization
in rat islet -cells and downstream insulin exocytosis. We recently showed that exocytotic SNARE
protein SNAP-25 directly binds and modulates rat islet -cell Kv 2.1 channel protein at the ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►jbc.org N Cui, Y Kang, Y He, YM Leung, H Xie, EA Pasyk, X … - Journal of Biological …, 2004 - ASBMB The ATP-sensitive potassium (K ATP ) channel in pancreatic islet beta cells consists of four
pore-forming (Kir6.2) subunits and four regulatory sulfonylurea receptor (SUR1) subunits. In
beta cells, the K ATP channel links intracellular metabolism to the dynamic regulation of ... Cited by 20 - Related articles - All 4 versions
- ►diabetesjournals.org [PDF] S Daniel, M Noda, SG Straub, GW Sharp - Diabetes, 1999 - Am Diabetes Assoc The mechanisms underlying the first phase of glucose- stimulated insulin release, the deterioration
of which marks the early stages of both type 1 and type 2 dia- betes, are essentially
unknown. Among many hypothe- ses, one holds that the first phase is due to a readily ... Cited by 116 - Related articles - BL Direct - All 5 versions
- ►physiology.org H Yoshikawa, Z Ma, A Bjorklund, V … - American Journal of …, 2004 - Am Physiological Soc Prolonged periods of " -cell rest" exert beneficial effects on insulin secretion from pancreatic islets
subjected to a high-glucose environment. Here, we tested for effects of short-term intermittent
rest achieved by diazoxide. Rat islets were cultured for 48 h with 27 mmol/l glucose ... Cited by 20 - Related articles - BL Direct - All 5 versions
