- ►diabetesjournals.org [PDF] E Gershonov, Y Shechter, M Fridkin - Diabetes, 1999 - Am Diabetes Assoc Insulin is a short-lived species in the circulatory system. After binding to its receptor sites and
transmission of its biological signals, bound insulin undergoes receptor- mediated endocytosis
and consequent degradation. An inactive insulin derivative that is not recognized by the ... Cited by 20 - Related articles - BL Direct - All 4 versions
Y Shechter, I Goldwaser, I Lavon, E Gershonov, B … - Drugs of the …, 2001 - journals.prous.com Most peptide and protein drugs are short-lived species in vivo, having a circulatory half-life of
several minutes. This is particularly valid for nonglycosylated proteins of a molecular mass less
than 50,000 daltons. The short lifetime of proteins in vivo is attributed to several ... Cited by 9 - Related articles - All 2 versions
E Gershonov, I Goldwaser, M Fridkin, Y Shechter - J. Med. Chem, 2000 - pubs.acs.org In this study we designed, prepared, and analyzed a water-soluble, long-acting insulin derivative
whose protracted action in vivo is based on a new principle rather than on slower absorption
rates of suspended insulin formulations. To this end, we have prepared (9- ... Cited by 19 - Related articles - BL Direct - All 4 versions
Y Shechter, L Preciado-Patt, G … - Proceedings of the …, 2001 - National Acad Sciences Polypeptide drugs are generally short-lived species in circulation. In this study, we have covalently
linked seven moieties of 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) to the amino groups of human
interferon-α2. The derivative thus obtained (FMS 7 –IFN-α2) has ≈4% the biological ... Cited by 18 - Related articles - BL Direct - All 7 versions
Y Shechter, H Tsubery, M Fridkin - Biochemical and Biophysical Research …, 2003 - Elsevier FMS 3 –insulin (2-sulfo-9-fluorenylmethoxycarbonyl) 3 –insulin is a water soluble, inactive-reactivated
derivative of insulin with protracted action in vivo. In this study we find that FMS 3 –insulin preserves
insulin's capacity to crystallize when associated with Zn 2+ ions or with basic protamine. ... Cited by 3 - Related articles - All 5 versions
Y Shechter, H Tsubery, M Fridkin - Biochemical and Biophysical Research …, 2003 - Elsevier Exendin-4, a glucagon-like peptide-1 agonist, is a relatively short-lived species in the circulatory
system in vivo. We have linked three moieties of 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) to
the three amino functions of exendin-4. FMS 3 –exendin-4 thus obtained has about 0.1% ... Cited by 3 - Related articles - BL Direct - All 3 versions
F Shojaee-Moradie, H Eckey, NC Jackson, A … - Diabetic …, 1998 - interscience.wiley.com To explore the possibility that insulin analogues designed to have restricted access to peripheral
tissues may display relative hepatoselectivity in vivo, N B1 -thyroxyl-insulin (B1-T4-Ins) and N
B1 -thyroxyl-aminohexanoyl insulin (B1-T4-AHA-Ins) were synthesized. These insulin ... Cited by 11 - Related articles - BL Direct - All 4 versions
L Benzi, P Cecchetti, A Ciccarone, A Pilo, G Di Cianni, … - Diabetes, 1994 - Am Diabetes Assoc The products of insulin metabolism generated in vitro and in vivo were compared in this
study. Monocytes from 10 control subjects were incubated with 125IA14-labeled insulin, acid
washed, and solubilized or reincubated in insulin-free binding buffer to study both ... Cited by 22 - Related articles - BL Direct - All 5 versions
Z Chap, T Ishida, J Chou, CJ Hartley, ML … - American Journal of …, 1987 - Am Physiological Soc First-pass hepatic extraction and metabolic effects ... ZVI CHAP, TOSHIHIKO ISHIDA, JESSE
CHOU, CRAIG J. HARTLEY, MARK L. ENTMAN, DIETRICH BRANDENBURG, RICHARD H.
JONES, AND JAMES B. FIELD Diabetes Research Center, St. Luke's Episcopal Hospital, ... Cited by 24 - Related articles - All 3 versions
- ►jbc.org H Tsubery, M Mironchik, M Fridkin, Y Shechter - Journal of Biological Chemistry, 2004 - ASBMB Polyethylene glycol (PEG)-conjugated therapeutic peptides/proteins have been shown to exhibit
clinical properties superior to those of their corresponding unmodified parent molecules.
However, the desirable pharmacological features gained by protein PEGylation become ... Cited by 23 - Related articles - BL Direct - All 4 versions
