E Lupia, SJ Elliot, O Lenz, F Zheng, M Hattori, … - Diabetes, 1999 - Am Diabetes Assoc Nonobese diabetic (NOD) mice develop glomeruloscle- rosis shortly after the
onset of diabetes. We showed that mesangial cells (MCs) from diabetic mice
exhibited a stable phenotypic switch, consisting of both increased IGF-1 ... Cited by 107 - Related articles - BL Direct - All 6 versions
SJ Elliot, LJ Striker, M Hattori, CW Yang, CJ … - Endocrinology, 1993 - Endocrine Soc Page 1. 0013.7227/93/1334-17%3$03.00/0 Endocrinology Copyright 0 1993 by The
Endocrine Society Vol. 133, No. 4 Printed in USA Mesangial ... Cited by 38 - Related articles - BL Direct - All 4 versions
SV McLennan, SYK Martell, DK Yue - Diabetologia, 2000 - Springer Aims/hypothesis. High glucose concentration de- creases the degradation of
mesangium matrix, an ac- tion substantially mediated by a reduction in the ac-
tivities of the matrix metalloproteinases (MMPs). Metalloproteinase-2 is ... Cited by 49 - Related articles - BL Direct - All 3 versions
D Del Prete, F Anglani, M Forino, M Ceol, P … - Diabetologia, 1997 - Springer Summary Regulation of mesangial matrix deposition is a dynamic phenomenon
involving synthetic and de- gradative processes. The latter involve a number of
matrix metalloproteinases (MMP) and tissue inhibi- tors of matrix ... Cited by 62 - Related articles - BL Direct - All 3 versions
SV McLennan, DK Yue, JR Turtle - Nephron, 2000 - content.karger.com Mesangial cells are known to secrete matrix metalloproteinases (MMPs). These
enzymes play a major role in the degradation and remodelling of extracellular
matrix, and alterations in their activity may contribute to the mesangium ... Cited by 52 - Related articles - BL Direct - All 6 versions
BD Schreiber, ML Hughes, GC Groggel - Clinical nephrology, 1995 - cat.inist.fr Diabetic nephropathy is characterized by mesangial cell proliferation and
expansion of the mesangial matrix. Insulin-like growth factor-I(IGF-I))
increases in the kidney early in experimental diabetes. The effect of IGF-I ... Cited by 41 - Related articles - BL Direct - All 2 versions
R Singh, RH Song, N Alavi, AA Pegoraro, AK … - Experimental nephrology, 2000 - content.karger.com Diabetic nephropathy is characterized by accumulation of mesangial matrix.
Glucose-induced inhibition of matrix-degrading enzymes such as collagenases is
believed to contribute to matrix accumulation. We have previously ... Cited by 99 - Related articles - BL Direct - All 6 versions
TA Jacot, GE Striker, M Stetler-Stevenson, LJ … - Laboratory investigation; a journal of technical …, 1996 - ncbi.nlm.nih.gov Mice transgenic for bovine growth hormone (bGH) develop progressive mesangial
sclerosis resulting in uremia. Mesangial cells from bGH mice were isolated to
determine whether the cells maintained a stable phenotypic change in the ... Cited by 62 - Related articles - BL Direct - All 2 versions
F Zheng, GE Striker, C Esposito, E Lupia, LJ … - Kidney international, 1998 - nature.com In this study, we induced diabetes in ROP and C57 mice to determine if the
glomerulosclerotic response was stimulus specific. We used the oligosyndactyly
mutation (Os), to produce a congenital 50% reduction in nephron number. ... Cited by 64 - Related articles - BL Direct - All 4 versions
SV McLennan, DJ Kelly, AJ Cox, Z Cao, JG … - Diabetologia, 2002 - Springer The accumulation of extracellular matrix (ECM) within the kidney is an
ultrastructural hallmark of di- abetic nephropathy and is directly linked to a
decline in renal function [1].This increase of ECM can result from either ... Cited by 88 - Related articles - BL Direct - All 5 versions
