- ►diabetesjournals.org [PDF] SA Metz, M Meredith, J Vadakekalam, ME … - Diabetes, 1999 - Am Diabetes Assoc A widely accepted genetically determined rodent model for human type 2 diabetes
is the Goto-Kakizaki (GK) rat; however, the lesion(s) in the pancreatic islets
of these rats has not been identified. Herein, intact islets from GK rats ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►physiology.org A Kowluru - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc We recently described novel regulatory roles for protein histidine
phosphorylation of key islet proteins (eg, nucleoside diphosphate kinase and
succinyl thiokinase) in insulin secretion from the islet -cell (Kowluru A. ... Cited by 19 - Related articles - BL Direct - All 4 versions
A Kowluru - Biochemical pharmacology, 2002 - Elsevier Using insulin-secreting cells, we previously demonstrated that specific proteins
associated with the cytosolic, secretory granule, and mitochondrial fractions
undergo a novel type of phosphorylation on their histidine residues. ... Cited by 25 - Related articles - BL Direct - All 6 versions
PHJ Nederkoorn, H Timmerman, D Timms, AJ … - Journal of Molecular Structure: THEOCHEM, 1998 - Elsevier An extended α-helical structural model of a G-protein-coupled receptor has been
combined with a G-protein structure to assess the ternary complex's potential to
function as a GTP synthase. The establishment of the structural constraints ... Cited by 18 - Related articles - All 2 versions
SJ Hughes, M Faehling, CW Thorneley, P … - Diabetes, 1998 - Am Diabetes Assoc We have used the whole-cell recording technique to determine whether
ATP-sensitive potassium (K[ATP]) currents, voltage-dependent Ca2+ currents, and
exocytosis are different in single beta-cells from pancreatic islets of ... Cited by 37 - Related articles - BL Direct - All 6 versions
SM Abdel-Halim, A Guenifi, A Khan, O … - Diabetes, 1996 - Am Diabetes Assoc The GK rat is a spontaneous model of NIDDM. The insulin response to 16.7 mmol/l
glucose was markedly impaired in both isolated perfused pancreas and isolated
islets from GK rats compared with control Wistar rats. Depolarization with ... Cited by 51 - Related articles - BL Direct - All 5 versions
[CITATION] GTP-binding proteins in the regulation of pancreatic β cell function
A Kowluru, RP Robertson, SA Metz - Diabetes Mellitus: A Fundamental and Clinical Text. …, 2000 Cited by 17 - Related articles
Y Okamoto, H Ishida, Y Tsuura, K Yasuda, S … - Diabetologia, 1995 - Springer Summr/ In spontaneously diabetic GK rats, insulin secretion from pancreatic beta
cells in response to glucose is selectively impaired, probably due to defi-
cient intracellular metabolism of glucose and im- paired closure of KAv ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org R Amin, HQ Chen, M Tannous, R Gibbs, A … - Journal of Pharmacology and Experimental …, 2002 - ASPET The majority of low molecular weight G proteins undergoes a series of
post-translational modification steps, eg, isoprenylation, at their C-terminal
cysteine, which seem to be critical for the transport of the modified ... Cited by 20 - Related articles - BL Direct - All 4 versions
ZC Ling, S Efendic, R Wibom, SM Abdel- … - Endocrinology, 1998 - ncbi.nlm.nih.gov Islets from Goto-Kakizaki (GK) rats from our colony, despite marked impairment
of glucose-induced insulin release, used glucose and produced CO2 at a rate 3
times that of islets from control Wistar rats. Almost all glucose used was ... Cited by 31 - Related articles
