- ►diabetesjournals.org [PDF] JC Henquin - Diabetes, 2000 - Am Diabetes Assoc Glucose stimulates insulin secretion by generating trig- gering and amplifying
signals in ß-cells. The triggering pathway is well characterized. It involves
the following sequence of events: entry of glucose by facilitated dif- ... Cited by 453 - Related articles - BL Direct - All 5 versions
SG Straub, GWG Sharp - Diabetes/Metabolism Reviews - interscience.wiley.com Glucose-stimulated biphasic insulin secretion involves at least two signaling
pathways, the KATP channel-dependent and KATP channel-independent pathways,
respectively. In the former, enhanced glucose metabolism increases the ... Cited by 156 - Related articles - BL Direct - All 3 versions
- ►nih.gov [PDF] M Gembal, P Gilon, JC Henquin - Journal of Clinical Investigation, 1992 - pubmedcentral.nih.gov Glucose stimulation of insulin release involves closure of ATP- sensitive K+
channels, depolarization, and Ca2+ influx in B cells. Mouse islets were used to
investigate whether glucose can still regulate insulin release when it ... Cited by 276 - Related articles - All 8 versions
P Maechler, CB Wollheim - Nature, 1999 - nature.com The hormone insulin is stored in secretory granules and released from the
pancreatic -cells by exocytosis 1 . In the consensus model of glucose-stimulated
insulin secretion, ATP is generated by mitochondrial metabolism, promoting ... Cited by 282 - Related articles - BL Direct - All 9 versions
V Seghers, M Nakazaki, F DeMayo, L Aguilar- … - Journal of Biological Chemistry, 2000 - ASBMB Sur1 knockout mouse β-cells lack K ATP channels and show spontaneous Ca 2+
action potentials equivalent to those seen in patients with persistent
hyperinsulinemic hypoglycemia of infancy, but the mice are normoglycemic ... Cited by 195 - Related articles - BL Direct - All 4 versions
CP ATP-DةPENDANTS, ET … - journees.hotel-dieu.com JC HENQUIN, M. ANELLO et Y. SATO* Les cellules β du pancréas endocrine
synthétisent l'insuline et la sécrètent en quantité et à une vitesse
appropriées pour que l'organisme puisse, selon les circonstances, ... Related articles - View as HTML
P Rorsman - Diabetologia, 1997 - Springer The central role of ions in the control of cellular excit- ability has been
recognized for more than a century and dates back to the pioneering work of
Ringer [1]. For a long time, electrical excitability was a property ... Cited by 180 - Related articles - BL Direct - All 3 versions
J Lang - European Journal of Biochemistry, 1999 - biochemie.uni-greifswald.de Secretion of the peptide hormone insulin from pancreatic b cells constitutes an
important step in the regulation of body homeostasis. Insulin is stored in large
dense core vesicles and released by exocytosis, a multistage process ... Cited by 212 - Related articles - View as HTML - BL Direct - All 6 versions
- ►rupress.org L Eliasson, X Ma, E Renstrom, S Barg, PO … - Journal of General Physiology, 2003 - jgp.rupress.org Measurements of membrane capacitance were applied to dissect the cellular
mechanisms underlying PKA-dependent and -independent stimulation of insulin
secretion by cyclic AMP. Whereas the PKA-independent ... Cited by 113 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] S Farfari, V Schulz, B Corkey, M Prentki - Diabetes, 2000 - Am Diabetes Assoc The hypothesis proposing that anaplerosis and cata- plerosis play an important
role in fuel signaling by providing mitochondrially derived coupling factors for
stimulation of insulin secretion was tested. A rise in citrate coincided ... Cited by 141 - Related articles - BL Direct - All 4 versions
