- ►diabetesjournals.org [PDF] Z Ling, M Van de Casteele, DL Eizirik, DG Pipeleers - Diabetes, 2000 - Am Diabetes Assoc Previous work has shown that interleukin-1 ( I L-1 ) alters protein expression in -cells. This alteration
is associated with cell death in isolated rat islets but not in isolated rat -cells. We examined whether
IL-1 pr e- treatment of isolated -cells influences their sensitiv- ity to toxic agents. After a ... Cited by 48 - Related articles - BL Direct - All 3 versions
Z Ling, M Van de Casteele, DL Eizirik, DG Pipeleers - Diabetes, 2000 - Am Diabetes Assoc Previous work has shown that interleukin-1 ( I L-1 ) alters protein expression in -cells. This alteration
is associated with cell death in isolated rat islets but not in isolated rat -cells. We examined whether
IL-1 pr e- treatment of isolated -cells influences their sensitiv- ity to toxic agents. After a ... Cited by 19 - Related articles
- ►endojournals.org Z Ling, MC Chen, A Smismans, D Pavlovic, F Schuit, … - Endocrinology, 1998 - Endocrine Soc The normal pancreatic ß-cell population exhibits intercellular differences in its responsiveness
to glucose. This cellular heterogeneity allows glucose to regulate, in a dose-dependent
manner, total rates of insulin synthesis and release. It may also predispose to intercellular ... Cited by 40 - Related articles - BL Direct - All 3 versions
D Pavlovic, MC Chen, CA Gysemans, C … - Eur. Cytokine …, 1999 - john-libbey-eurotext.fr Summary : Combinations of cytokines, including interleukin-1beta (IL-1beta) and interferon-gamma
(IFN-gamma), induce nitric oxide (NO) production and cell death in pancreatic islet cells. We
have previously shown that these events are preceded by increased expression of the ... Cited by 44 - Related articles - BL Direct - All 6 versions
- ►endojournals.org D Liu, M Darville, DL Eizirik - Endocrinology, 2001 - Endocrine Soc Type 1 diabetes mellitus (T1DM) is an autoimmune disease caused by progressive destruction
of insulin-producing pancreatic ß-cells. Both viral infections and the cytokines interleukin-1ß
(IL-1ß) and interferon- (IFN- ) have been suggested as potential mediators of ß-cell death ... Cited by 34 - Related articles - All 2 versions
D Pipeleers, A Hoorens, M Marichal-Pipeleers, M Van … - Diabetes, 2001 - Am Diabetes Assoc Studies on the pathogenesis of type 1 diabetes have mainly focused on the role of the immune
system in the destruction of pancreatic beta-cells. Lack of data on the cellular and molecular
events at the beta-cell level is caused by the inaccessibility of these cells during ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AK Cardozo, M Kruhøffer, R Leeman, T Ørntoft, DL … - Diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from the selective destruction of
insulin-producing β-cells. Cytokines may contribute to pancreatic β-cell death in type 1
diabetes. β-cell exposure to interleukin (IL)-1β induces functional impairment, whereas β- ... Cited by 145 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MI Darville, YS Ho, DL Eizirik - Endocrinology, 2000 - Endocrine Soc Reactive oxygen species play an important role in the cytotoxic effect of inflammatory cytokines
on pancreatic ß-cells in type 1 diabetes mellitus. The antioxidant enzyme manganese superoxide
dismutase (MnSOD) is part of the cellular defenses against these deleterious radicals. ... Cited by 63 - Related articles - BL Direct - All 2 versions
D Pipeleers, M Van de Winkel - Proc Natl Acad Sci USA, 1986 - National Acad Sciences Proc. Natl. Acad. Sci. USA Vol. 83, pp. 5267-5271, July 1986 Medical Sciences ... Pancreatic
B cells possess defense mechanisms against cell-specific toxicity ...
(diabetes/alloxan/streptozotocin/islet cell surface antibodies) ... D. PIPELEERS* AND M. ... Cited by 78 - Related articles - All 8 versions
- ►endojournals.org D Liu, AK Cardozo, MI Darville, DL Eizirik - Endocrinology, 2002 - Endocrine Soc Viral infections may trigger the autoimmune assault leading to type 1 diabetes mellitus.
Double-stranded RNA (dsRNA) is produced by many viruses during their replicative cycle. The
dsRNA, tested as synthetic poly(IC) (PIC), in synergism with the proinflammatory ... Cited by 51 - Related articles - BL Direct - All 4 versions
