FC Schuit, P Huypens, H Heimberg, DG Pipeleers - Diabetes, 2001 - Am Diabetes Assoc Nutrient homeostasis is known to be regulated by pancreatic islet tissue. The function of islet
β-cells is controlled by a glucose sensor that operates at physiological glucose concentrations
and acts in synergy with signals that integrate messages originating from hypothalamic ... Cited by 183 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] XJ Yang, LM Kow, T Funabashi, CV Mobbs - Diabetes, 1999 - Am Diabetes Assoc Glucose-responsive neurons in the ventromedial hypo- thalamus (VMH) are stimulated when
glucose increases from 5 to 20 mmol/l and are thought to play an essential role in regulating
metabolism. The present studies exam- ined the role of glucose metabolism in the ... Cited by 186 - Related articles - BL Direct - All 5 versions
I Roncero, E Alvarez, P Vazquez, E … - Journal of …, 2000 - interscience.wiley.com Abstract: Recently, the description of glucokinase mRNA in certain neuroendocrine cells has
opened new ways to characterize this enzyme in the rat brain. In this study, we found glucokinase
mRNA and a similar RNA splicing pattern of the glucokinase gene product in rat ... Cited by 67 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] RM Lynch, LS Tompkins, HL Brooks, AA Dunn-Meynell, … - Diabetes, 2000 - Am Diabetes Assoc The brain contains a subpopulation of glucosensing neu- rons that alter their firing rate in response
to elevated glucose concentrations. In pancreatic ß-cells, gluco- kinase (GK), the rate-limiting
enzyme in glycolysis, medi- ates glucose-induced insulin release by regulating intra- ... Cited by 112 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Shiota, C Postic, Y Fujimoto, TL Jetton, K Dixon, D … - Diabetes, 2001 - Am Diabetes Assoc Transgenic mice that overexpress the entire glucokinase (GK) gene locus have been previously
shown to be mildly hypoglycemic and to have improved tolerance to glucose. To determine whether
increased GK might also prevent or diminish diabetes in diet-induced obese animals, we ... Cited by 59 - Related articles - BL Direct - All 7 versions
E Alvarez, I Roncero, JA Chowen, P … - Journal of …, 2002 - interscience.wiley.com Our previous description of functional glucokinase isoforms in the rat brain has opened new
questions concerning the presence of glucokinase regulatory protein in the brain and the functional
role of its interactions with glucokinase. In this study, we found glucokinase regulatory ... Cited by 62 - Related articles - BL Direct - All 5 versions
HBT Christesen, BB Jacobsen, S Odili, C Buettger, A … - Diabetes, 2002 - Am Diabetes Assoc In this study, a second case of hyperinsulinemic hypoglycemia due to activation of glucokinase
is reported. The 14-year-old proband had a history of neonatal hypoglycemia, treated with
diazoxide. He was admitted with coma and convulsions due to nonketotic hypoglycemia. ... Cited by 118 - Related articles - BL Direct - All 6 versions
E Alvarez, I Roncero, JA Chowen, B … - Journal of …, 1996 - interscience.wiley.com Abstract: Evidence that glucagon-like peptide-1 (GLP-1) (7–36) amide functions as a novel neuropeptide
prompted us to study the gene expression of its receptor in rat brain. Northern blot analysis showed
transcripts of similar size in RINm5F cells, hypothalamus, and brainstem. First-strand ... Cited by 83 - Related articles - BL Direct - All 3 versions
- ►jbc.org J Seoane, A Barbera, S Telemaque-Potts, CB … - Journal of Biological …, 1999 - ASBMB Zucker diabetic fatty rats develop type 2 diabetes concomitantly with peripheral insulin
resistance. Hepatocytes from these rats and their control lean counterparts have been
cultured, and a number of key parameters of glucose metabolism have been determined. ... Cited by 38 - Related articles - BL Direct - All 5 versions
K Fujimoto, T Sakata, K Arase, K Kurata, Y Okabe, T … - Life sciences, 1985 - ncbi.nlm.nih.gov D-glucosamine, 2-amino-2-deoxy-D-glucose, is known to be an endogenous glucose analogue
and to antagonize glucose uptake and metabolism. The present experiments were aimed to
clarify effects of glucosamine and related chemical substances on ingestive behavior, as ... Cited by 28 - Related articles - All 2 versions
