H Kato, M Ohue, K Kato, A Nomura, K … - Diabetes, 2001 - Am Diabetes Assoc The mechanism by which the specific β 3 -adrenoceptor agonist AJ-9677 relieves
insulin resistance in vivo was investigated by studying its effects in the white
and brown adipose tissues of the KK-A y /Ta diabetic obese mouse model. ... Cited by 31 - Related articles - BL Direct - All 4 versions
DOM Model - DIABETES, 2001 - Am Diabetes Assoc The mechanism by which the specific 3 -adrenoceptor agonist AJ-9677 relieves
insulin resistance in vivo was investigated by studying its effects in the white
and brown adipose tissues of the KK-A y /Ta diabetic obese mouse model. ... Related articles
RL Dow - eid, 1997 - informahealthcare.com During the last decade a number of β3-adrenergic receptor ago- nists have been
advanced to clinical trials. The results of human studies to date have been
disappointing, with respect to sus- tained increases in metabolic rate and ... Cited by 24 - Related articles - All 4 versions
H Harada, Y Hirokawa, K Suzuki, Y Hiyama, M … - Chemical & pharmaceutical bulletin, 2005 - J-STAGE AR is located on the surface of both white and brown adipocytes and is known to
be stimulated by endogenous cat- echolamines, adrenalin, and noradrenaline. It
has also been reported that b 3 -AR receptor plays a significant role in ... Cited by 13 - Related articles - All 6 versions
CJ De Souza, BF Burkey - Current pharmaceutical design, 2001 - ingentaconnect.com Abstract: In the early 1980s, an “atypical” beta-adrenergic receptor was
discovered and subsequently called the beta 3 -adrenoceptor (β 3 -AR). Agonists
of the β 3 -AR were observed to simultaneously increase Cited by 37 - Related articles - BL Direct - All 3 versions
FW Sum, A Gilbert, AM Venkatesan, K Lim, V … - Bioorganic & Medicinal Chemistry Letters, 1999 - Elsevier CL316243 is a highly selective and potent β 3 -adrenergic receptor agonist, and
has been shown in rodent models to be an effective agent for treating obesity
and Type II diabetes. To improve the oral absorption and pharmacokinetic ... Cited by 15 - Related articles - BL Direct - All 4 versions
S Francke - Current Opinion in Investigational Drugs, 2002 - biomedcentral.com Introduction During the past two decades, obesity has developed into an epidemic
problem both in Western and developing countries [452237]. On a worldwide level,
obesity is beginning to replace malnutrition and infectious diseases as the ... Cited by 5 - Related articles - View as HTML - BL Direct - All 3 versions
- ►physiology.org JG Granneman, M Burnazi, Z Zhu, LA … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc 3 -Adrenergic receptors (AR) are nearly exclusively expressed in brown and white
adipose tissues, and chronic activation of these receptors by selective agonists
has profound anti-diabetes and anti-obesity effects. This study examined ... Cited by 30 - Related articles - BL Direct - All 4 versions
LL Brockunier, MR Candelore, MA Cascieri, Y … - Bioorganic & Medicinal Chemistry Letters, 2001 - Elsevier Elevation of metabolic rate by activation of the human β 3 adrenergic receptor
(AR) may be an effective approach toward the treatment of obesity.[1]
Heretofore, our efforts have largely focused on the preparation of ... Cited by 8 - Related articles - BL Direct - All 4 versions
