- ►diabetesjournals.org ES Buhl, N Jessen, O Schmitz, SB Pedersen, O … - Diabetes, 2001 - Am Diabetes Assoc Recent studies have demonstrated that chronic administration of AICAR
(5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside), an activator of the AMP-activated protein
kinase, increases hexokinase activity and the contents of total GLUT4 and glycogen in rat ... Cited by 121 - Related articles - BL Direct - All 6 versions
- ►physiology.org BF Holmes, EJ Kurth-Kraczek, WW … - Journal of Applied …, 1999 - Am Physiological Soc This study was designed to determine whether chronic chemical activation of AMP-activated
protein kinase (AMPK) would increase glucose transporter GLUT-4 and hexokinase in muscles
similarly to periodic elevation of AMPK that accompanies endurance exercise training. ... Cited by 255 - Related articles - BL Direct - All 5 versions
- ►physiology.org EO Ojuka, LA Nolte, JO Holloszy - Journal of Applied Physiology, 2000 - Am Physiological Soc Exercise acutely stimulates muscle glucose transport and also brings about an adaptive increase
in the capacity of muscle for glucose uptake by inducing increases in GLUT-4 and
hexokinase. 1 Recent studies have provided evidence that activation of AMP protein ... Cited by 98 - Related articles - BL Direct - All 3 versions
- ►physiology.org WW Winder, BF Holmes, DS Rubink, EB … - Journal of applied …, 2000 - Am Physiological Soc Muscle contraction causes an increase in activity of 5'-AMP-activated protein kinase (AMPK).
This study was designed to determine whether chronic chemical activation of AMPK will increase
mitochondrial enzymes, GLUT-4, and hexokinase in different types of skeletal muscle of ... Cited by 298 - Related articles - BL Direct - All 5 versions
N Fujii, T Hayashi, MF Hirshman, JT Smith, SA … - … and biophysical research …, 2000 - Elsevier The 5′AMP-activated protein kinase (AMPK) is stimulated by contractile activity in rat skeletal
muscle. AMPK has emerged as an important signaling intermediary in the regulation of cell metabolism
being linked to exercise-induced changes in muscle glucose and fatty acid metabolism. In ... Cited by 186 - Related articles - BL Direct - All 5 versions
- ►physiology.org D Zheng, PS MacLean, SC Pohnert, JB … - Journal of Applied …, 2001 - Am Physiological Soc Skeletal muscle GLUT-4 transcription in response to treatment with 5-aminoimidazole-4-carboxamide
-1- -D-ribofuranoside (AICAR), a known activator of AMP-activated protein kinase (AMPK), was
studied in rats and mice. The increase in GLUT-4 mRNA levels in response to a single ... Cited by 134 - Related articles - BL Direct - All 3 versions
W Derave, H Aj, J Ihlemann, LA Witters, S … - DIABETES-NEW …, 2000 - Am Diabetes Assoc 5 AMP-activated protein kinase (AMPK) has been sug- gested to be a key regulatory protein
in exercise sig- naling of muscle glucose transport. To test this hypoth- esis, we investigated
whether muscle glycogen levels affect AMPK activation and glucose transport stimula- ... Cited by 126 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] EJ Kurth-Kraczek, MF Hirshman, LJ Goodyear, WW … - Diabetes, 1999 - Am Diabetes Assoc It has previously been reported that exercise causes an increase in glucose uptake in skeletal
muscle and also an increase in 5 AMP–activated protein kinase (AMPK) activit y.
5-Aminoimidazole-4-carboxamide-1- - D - ribof u- ranoside (AICA-riboside), an analog of ... Cited by 322 - Related articles - BL Direct - All 4 versions
- ►physiology.org [PDF] CA Hutber, DG Hardie, WW Winder - American Journal of …, 1997 - Am Physiological Soc MALONYL-CoA is believed to be an important regulator of fat metabolism in skeletal muscle,
where changes in its concentration might vary the degree of inhibition of carnitine palmitoyltransferase
1, the enzyme that trans- fers fatty acids into the mitochondria for P-oxidation (14,18,24). ... Cited by 144 - Related articles - BL Direct - All 3 versions
- ►physiology.org N Jessen, R Pold, ES Buhl, LS Jensen, O … - Journal of Applied …, 2003 - Am Physiological Soc Physical activity is known to increase insulin action in skeletal muscle, and data have indicated
that 5'-AMP-activated protein kinase (AMPK) is involved in the molecular mechanisms behind
this beneficial effect. 5-Aminoimidazole-4-carboxamide-1- -D-ribofuranoside (AICAR) can ... Cited by 80 - Related articles - BL Direct - All 5 versions
