RL Dobbins, LS Szczepaniak, B Bentley, V … - Diabetes, 2001 - Am Diabetes Assoc Cross-sectional studies in human subjects have used 1 H magnetic resonance
spectroscopy (HMRS) to demonstrate that insulin resistance correlates more
tightly with the intramyocellular lipid (IMCL) concentration than with any ... Cited by 158 - Related articles - BL Direct - All 4 versions
- ►physiology.org BA Ellis, A Poynten, AJ Lowy, SM Furler, DJ … - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc Long-chain acyl-CoAs (LCACoA) are an activated lipid species that are key
metabolites in lipid metabolism; they also have a role in the regulation of
other cellular processes. However, few studies have linked LCACoA content ... Cited by 149 - Related articles - BL Direct - All 4 versions
- ►jbc.org G Perdomo, SR Commerford, AMT Richard, … - Journal of Biological Chemistry, 2004 - ASBMB Skeletal muscle insulin resistance may be aggravated by intramyocellular
accumulation of fatty acid-derived metabolites that inhibit insulin signaling.
We tested the hypothesis that enhanced fatty acid oxidation in myocytes ... Cited by 70 - Related articles - BL Direct - All 5 versions
S Jacob, J Machann, K Rett, K Brechtel, A … - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc Insulin resistance plays an important role in the patho- genesis of type 2
diabetes; however, the multiple mech- anisms causing insulin resistance are not
yet fully understood. The aim of this study was to explore the pos- sible ... Cited by 358 - Related articles - BL Direct - All 4 versions
- ►physiology.org DE Kelley, B Goodpaster, RR Wing, JA … - American Journal of Physiology- Endocrinology And …, 1999 - Am Physiological Soc The current study was undertaken to investigate fatty acid metabolism by
skeletal muscle to examine potential mechanisms that could lead to increased
muscle triglyceride in obesity. Sixteen lean and 40 obese research ... Cited by 361 - Related articles - All 5 versions
DIW Phillips, S Caddy, V Ilic, BA Fielding, KN … - Metabolism, 1996 - Elsevier Intracellular triglyceride (TG) is an important energy source for skeletal
muscle. However, recent evidence suggests that if muscle contains abnormally
high TG stores its sensitivity to insulin may be reduced, and this could ... Cited by 250 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BH Goodpaster, J He, S Watkins, DE Kelley - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc We examined the hypothesis that an excess accumulation of intramuscular lipid
(IMCL) is associated with insulin resistance and that this may be mediated by
the oxidative capacity of muscle. Nine sedentary lean (L) and 11 obese (O) ... Cited by 294 - Related articles - BL Direct - All 5 versions
K Levin, H Daa Schroeder, FP Alford, H Beck- … - Diabetologia, 2001 - Springer Over the last decade, the role of excessive lipid avail- ability in the
pathogenesis of Type II (non-insulin-de- pendent) diabetes mellitus has been the
subject of in- creasing attention [1ą4]. It has recently been suggest- ed ... Cited by 74 - Related articles - BL Direct - All 3 versions
ND Oakes, GJ Cooney, S Camilleri, DJ … - Diabetes, 1997 - Am Diabetes Assoc To elucidate cellular mechanisms of insulin resistance induced by excess dietary
fat, we studied conscious chronically high-fat-fed (HFF) and control chow
diet-fed rats during euglycemic-hyperinsulinemic (560 pmol/l plasma ... Cited by 247 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] DE Kelley, LJ Mandarino - Diabetes, 2000 - Am Diabetes Assoc For many years, the Randle glucose fatty acid cycle has been invoked to explain
insulin resistance in skeletal muscle of patients with type 2 diabetes or
obesity. Increased fat oxidation was hypothesized to reduce glucose ... Cited by 359 - Related articles - BL Direct - All 4 versions
