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Scholar Results 1 - 10 of about 101 related to Muñoz: Effects of tungstate, a new potential oral antidiabetic agent, in Zucker diabetic fatty rats. (0.12 sec) 

Effects of tungstate, a new potential oral antidiabetic agent, in Zucker diabetic fatty rats


MC Muñoz, A Barberà, J Domínguez, J … - Diabetes, 2001 - Am Diabetes Assoc
Tungstate was orally administered to 7.5-week-old male Zucker diabetic fatty
(ZDF) rats that already showed moderate hyperglycemia (180 ± 16 mg/dl). The
animals became normoglycemic for ∼10 days. Then, glycemia started to rise ...
Cited by 13 - Related articles - BL Direct - All 4 versions

Tungstate stimulates insulin release and inhibits somatostatin output in the perfused rat …


RA Silvestre, EM Egido, R Hernández, J … - European journal of pharmacology, 2005 - Elsevier
In the rat pancreas, infusion of sodium-tungstate stimulates basal insulin
release in a dose-dependent manner. We have studied tungstate's effects on the
insulin secretion elicited by various B-cell secretagogues. Somatostatin ...
Cited by 3 - Related articles - All 3 versions

[CITATION] On the determination of basal glucose production rate in patients with type 2 (non-insulin- …


H Nielsen, O Beck, H Nielsen - Diabetologia, 1990
Cited by 3 - Related articles

Phosphorylation events implicating p38 and PI3K mediate tungstate-effects in MIN6 beta …


S Piquer, S Barceló-Batllori, M Julià, N … - Biochemical and Biophysical Research …, 2007 - Elsevier
Oral administration of sodium tungstate is an effective treatment for diabetes
in animal models. Several lines of evidence indicate the pancreatic beta cell as
one of the targets of tungstate action. Here, we examined the molecular ...
Cited by 4 - Related articles - All 5 versions

Effects of tungstate in neonatally streptozotocin-induced diabetic rats: mechanism leading …


A Barbera, J Fernandez-Alvarez, A Truc, R … - Diabetologia, 1997 - Springer
When adult rats injected with streptozotocin (STZ- diabetic rats) were treated
orally with tungstate a re- duction in blood glucose levels and a normalization
of hepatic glucose metabolism was observed [1]. Tungstate administration ...
Cited by 46 - Related articles - BL Direct - All 5 versions

Modulation of glucose transporters in rat diaphragm by sodium tungstate


MD Girón, JJ Caballero, AM Vargas, MD … - FEBS letters, 2003 - Elsevier
Oral administration of sodium tungstate is an effective treatment for diabetes
in animal models. We examined the effects of 6 weeks of oral administration of
tungstate on glucose transporters (GLUT) in streptozotocin-induced diabetic ...
Cited by 13 - Related articles - All 7 versions

The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin …


JE Dominguez, MC Munoz, D Zafra, I Sanchez- … - Journal of Biological Chemistry, 2003 - ASBMB
Sodium tungstate is a powerful antidiabetic agent when administered orally. In
primary cultured hepatocytes, tungstate showed insulin-like actions, which led
to an increase in glycogen synthesis and accumulation. However, this ...
Cited by 22 - Related articles - BL Direct - All 4 versions

Influence of food and diabetes on pharmacokinetics of sodium tungstate in rat


S Le Lamer-Dechamps, P Poucheret, G Cros, … - International journal of pharmaceutics, 2002 - Elsevier
In this paper, the influence of food and diabetes on the pharmacokinetics of
sodium tungstate in rat was investigated. The compound was administered
intravenously (9 mg/kg) and orally in the form of solution (36 mg/kg). An ...
Cited by 5 - Related articles - All 3 versions

[CITATION] Multi-functional glucose-6-phosphatase of the endoplasmic reticulum and nuclear …


RC Nordlie - Membranes and Transport, 1982
Cited by 5 - Related articles

[CITATION] The inhibition of glucose-6-phosphatase by phlorizin and structurally related compounds.


C Zerr, WB Novoa - Biochemical and biophysical research communications, 1968 - ncbi.nlm.nih.gov
1: Biochem Biophys Res Commun. 1968 Jul 26;32(2):129-33. The inhibition of
glucose-6-phosphatase by phlorizin and structurally related compounds. ...
Cited by 6 - Related articles


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