- ►diabetesjournals.org E Breda, MK Cavaghan, G Toffolo, KS Polonsky, C … - Diabetes, 2001 - Am Diabetes Assoc The simultaneous assessment of quantitative indexes of insulin secretion and action in a single
individual is important when quantifying their relative role in the evolution of glucose tolerance
in different physiopathological states. Available methods quantify these indexes in ... Cited by 98 - Related articles - BL Direct - All 4 versions
- ►physiology.org G Toffolo, E Breda, MK Cavaghan, DA … - American Journal of …, 2001 - Am Physiological Soc Availability of quantitative indexes of insulin secretion is important for definition of the alterations
in -cell responsivity to glucose associated with different physiopathological states. This is presently
possible by using the intravenous glucose tolerance test (IVGTT) in conjunction with the ... Cited by 51 - Related articles - BL Direct - All 3 versions
- ►endojournals.org A Caumo, RN Bergman, C Cobelli - Journal of Clinical Endocrinology & …, 2000 - Endocrine Soc In this report a new approach is introduced that allows estimation of insulin sensitivity (S I ) from
orally ingested glucose during an oral glucose tolerance test (OGTT) or a meal glucose tolerance
test (MGTT) in normal subjects. The method hinges on the classic minimal model of ... Cited by 68 - Related articles - BL Direct - All 5 versions
E Breda, G Toffolo, KS Polonsky, C Cobelli - Diabetes, 2002 - Am Diabetes Assoc The availability of quantitative indexes describing β-cell function in normal life conditions is important
for the characterization of impaired mechanisms of insulin secretion in pathophysiological
states. Recently, an oral C-peptide minimal model has been proposed and applied to ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►endojournals.org R Hovorka, L Chassin, SD Luzio, R Playle, DR … - Journal of Clinical …, 1998 - Endocrine Soc A model-based method was developed to quantify pancreatic ß-cell responsiveness during a
meal tolerance test (MTT). C peptide secretion was related in a linear fashion to glucose
concentration, whereas the standard population model was used to derive transfer rate ... Cited by 40 - Related articles - BL Direct - All 5 versions
C Della Man, A Caumo, C Cobelli - IEEE Transactions on …, 2002 - ieeexplore.ieee.org Abstract Recently, a new approach has been proposed to estimate insulin sensitivity (S/sub
I/) from an oral glucose tolerance test or a meal using an "integral equation". Here, we improve
on the "integral equation" by resorting to a "differential equation" approach. The classic ... Cited by 51 - Related articles - All 4 versions
A Cretti, M Lehtovirta, E Bonora, B Brunato … - European Journal of …, 2001 - interscience.wiley.com DesignFifty-six subjects were studied. A minimal analogic model of β-cell secretion during the
OGTT was applied to all OGTTs (see below). The amount of insulin secreted over 120' in response
to oral glucose (OGTT-ISR; Insulin Units 120' −1 m −2 BSA) and an index of β-cell ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►physiology.org A Mari, O Schmitz, A Gastaldelli, T … - American Journal of …, 2002 - Am Physiological Soc We investigated -cell function and its relationship to insulin sensitivity in 17 normal
volunteers. For insulin secretion (derived by C-peptide deconvolution), a mathematical model
was applied to 24-h triple-meal tests (MT) as well as oral glucose tolerance tests (OGTT); ... Cited by 89 - Related articles - BL Direct - All 5 versions
- ►physiology.org C Dalla Man, KE Yarasheski, A Caumo, H … - American Journal of …, 2005 - Am Physiological Soc Measuring insulin sensitivity in the presence of physiological changes in glucose and insulin
concentrations, eg, during a meal or OGTT, is important to better understand insulin resistance
in a variety of metabolic conditions. Recently, two oral minimal models have been ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►physiology.org C Dalla Man, A Caumo, R Basu, R Rizza, … - American Journal of …, 2004 - Am Physiological Soc Measuring insulin sensitivity during the physiological milieu of oral glucose perturbation, eg,
a meal or an oral glucose tolerance test, would be extremely valuable but difficult since the rate
of appearance of absorbed glucose is unknown. The reference method is a tracer ... Cited by 35 - Related articles - BL Direct - All 3 versions
