C Gerhardinger, KD McClure, G Romeo, F Podestà, M … - Diabetes, 2001 - Am Diabetes Assoc IGF-I promotes the survival of multiple cell types by activating the IGF-I receptor (IGF-IR), which
signals downstream to a serine/threonine kinase termed Akt. Because in diabetes vascular and
neural cells of the retina undergo accelerated apoptosis, we examined IGF-I synthesis ... Cited by 43 - Related articles - BL Direct - All 4 versions
WL Lowe, RZ Florkiewicz, MA Yorek, RG … - Metabolism, clinical and …, 1995 - cat.inist.fr The underlying etiology of diabetic microvascular disease remains unknown. To examine the
potential contribution of basic fibroblast growth factor(bFGF), which is an angiogenic factor, and
insulin-like growth factor-I(IGF-I) to the development of diabetic microvascular disease, ... Cited by 29 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] R Burgos, C Mateo, A Canton, C Hernandez, J … - Diabetes Care, 2000 - Am Diabetes Assoc F rom the Diabetes Research Unit (RB, AC, CH, JM, RS) and the Ophthalmology Department
(CM), Hospital General Universitari Vall d'Hebron, Barcelona, Spain. A dd ress correspondence
and reprint requests to Dr. R. Simó, Diabetes Research Unit, Endocrinology Divi- sion, ... Cited by 57 - Related articles - BL Direct - All 4 versions
PE Spoerri, EA Ellis, RW Tarnuzzer, MB Grant - Growth Hormone & IGF …, 1998 - Elsevier Human retinal endothelial cell (HREC) cultures of diabetic and non-diabetic origin were examined
for the production of insulin-like growth factor I (IGF-I), IGF-I receptor and IGF-binding proteins
(IGFBPs) using colloidal gold quantitative immunocytochemistry and quantitative reverse ... Cited by 36 - Related articles - BL Direct - All 3 versions
E Averbukh, O Weiss, M Halpert, R Yanko, R Moshe, I … - Metabolism, 1998 - Elsevier Hypoxia is the main stimulus for neovascularization in the retina. Insulin-like growth factor-I
(IGF-I) is thought to be one of the mediators of this process. Severe persistent hypoxia, as occurs
in central retinal artery occlusion, is associated with less retinal neovascularization than ... Cited by 32 - Related articles - BL Direct - All 5 versions
R Simó, A Lecube, RM Segura, J Garcı́a Arumí, C … - American journal of …, 2002 - Elsevier RESULTS: Vitreal levels of both free IGF-1 and VEGF were higher in diabetic patients with PDR
than in control subjects (P < .01, and P < .0001, respectively). After adjusting for total intravitreous
protein concentration, VEGF (ng/mg of proteins) remained significantly higher in diabetic ... Cited by 51 - Related articles - All 16 versions
RP Danis, DP Bingaman - Ophthalmology, 1997 - ncbi.nlm.nih.gov OBJECTIVE: Human recombinant insulin-like growth factor-1 (hrIGF-1), a ubiquitous angiogenic
growth factor, was injected into the vitreous cavity of pigs to investigate the clinical and histopathologic
consequences of supraphysiologic levels of this angiogenic growth factor on the retinal ... Cited by 43 - Related articles - BL Direct - All 5 versions
[CITATION] Systemic levels contribute significantly to increased intraocular IGF-I, IGF-II and IGF …
J Zhang, C Gerhardinger, M Lorenzi - Diabetes, 2002 - Am Diabetes Assoc Diabetic retinal microangiopathy is characterized by increased permeability, leukostasis,
microthrombosis, and apoptosis of capillary cells, all of which could be caused or compounded
by activation of complement. In this study, we observed deposition of C5b-9, the terminal ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►iovs.org [PDF] CP Burren, JL Berka, SR Edmondson, GA Werther, … - … ophthalmology & visual …, 1996 - ARVO Purpose. To localize mRNAs for insulin-like growth factor (IGF)-I, IGF-I receptor (IGF-IR), and
IGF binding protein (BP)-l to IGFBP-6 in the rat eye. Methods. cDNA sequences for IGF-I,
IGF-IR, and IGFBP-1 to IGFBP-6 were used to synthesize 35 S-CTP labeled antisense ... Cited by 52 - Related articles - BL Direct - All 3 versions
