- ►diabetesjournals.org TM Pederson, DL Kramer, CM Rondinone - Diabetes, 2001 - Am Diabetes Assoc Insulin receptor substrate (IRS)-1 protein expression is markedly reduced in
many insulin-resistant states, although the mechanism for this downregulation is
unclear. In this study, we have investigated the early events in the ... Cited by 141 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] XJ Sun, JL Goldberg, LY Qiao, JJ Mitchell - Diabetes, 1999 - Am Diabetes Assoc Insulin receptor substrate (IRS) proteins are important intracellular molecules
that mediate insulin receptor tyrosine kinase signaling. A decreased content of
IRS proteins has been found in insulin-resistant states in animals, humans, ... Cited by 141 - Related articles - BL Direct - All 5 versions
- ►endojournals.org T Haruta, T Uno, J Kawahara, A Takano, K … - Molecular Endocrinology, 2000 - Endocrine Soc Insulin receptor substrate-1 (IRS-1) is a major substrate of the insulin
receptor and acts as a docking protein for Src homology 2 domain containing
signaling molecules that mediate many of the pleiotropic actions of ... Cited by 193 - Related articles - BL Direct - All 2 versions
J Li, K DeFea, RA Roth - Journal of Biological Chemistry, 1999 - ASBMB Serine/threonine phosphorylation of insulin receptor substrate 1 (IRS-1) has
been implicated as a negative regulator of insulin signaling. Prior studies have
indicated that this negative regulation by protein kinase C involves the ... Cited by 189 - Related articles - BL Direct - All 5 versions
- ►nih.gov R Zhande, JJ Mitchell, J Wu, XJ Sun - Molecular and Cellular Biology, 2002 - Am Soc Microbiol Insulin receptor substrate 1 (IRS-1) plays an important role in the insulin
signaling cascade. In vitro and in vivo studies from many investigators have
suggested that lowering of IRS-1 cellular levels may be a mechanism of ... Cited by 122 - Related articles - BL Direct - All 6 versions
- ►jbc.org MW Greene, H Sakaue, L Wang, DR Alessi, … - Journal of Biological Chemistry, 2003 - ASBMB Ser/Thr phosphorylation of insulin receptor substrate-1 (IRS-1) is a negative
regulator of insulin signaling. One potential mechanism for this is that Ser/Thr
phosphorylation decreases the ability of IRS-1 to be ... Cited by 116 - Related articles - BL Direct - All 4 versions
- ►endojournals.org K Egawa, N Nakashima, PM Sharma, H … - Endocrinology, 2000 - Endocrine Soc Recently, we have reported that the overexpression of a membrane-targeted
phosphatidylinositol (PI) 3-kinase (p110CAAX) stimulated p70S6 kinase, Akt,
glucose transport, and Ras activation in the absence of insulin but ... Cited by 57 - Related articles - BL Direct - All 3 versions
- ►nih.gov L Rui, V Aguirre, JK Kim, GI Shulman, A Lee, … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Serine/threonine phosphorylation of IRS-1 might inhibit insulin signaling, but
the relevant phosphorylation sites are difficult to identify in cultured cells
and to validate in isolated tissues. Recently, we discovered that ... Cited by 310 - Related articles - BL Direct - All 11 versions
- ►jbc.org L Rui, TL Fisher, J Thomas, MF White - Journal of Biological Chemistry, 2001 - ASBMB Insulin and insulin-like growth factor-1 (IGF-1) regulate metabolism and body
growth through homologous receptor tyrosine kinases that phosphorylate the
insulin receptor substrate (IRS) proteins. IRS-2 is an important IRS ... Cited by 113 - Related articles - BL Direct - All 4 versions
- ►whitelabs.org [PDF] V Aguirre, ED Werner, J Giraud, YH Lee, SE … - Journal of Biological Chemistry, 2002 - ASBMB Serine phosphorylation of insulin receptor substrate-1 (IRS-1) inhibits insulin
signal transduction in a variety of cell backgrounds, which might contribute to
peripheral insulin resistance. However, because of the large number of ... Cited by 377 - Related articles - All 7 versions
