- ►diabetesjournals.org GC Yaney, VN Civelek, AM Richard, JS Dillon … - Diabetes, 2001 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) is the most potent physiological incretin for
insulin secretion from the pancreatic β-cell, but its mechanism of action has
not been established. It interacts with specific cell-surface receptors, ... Cited by 47 - Related articles - BL Direct - All 5 versions
P Masiello, M Novelli, M Bombara, V … - Metabolism, 2002 - Elsevier This study intended to test the hypothesis that intracellular lipolysis in the
pancreatic [beta ] cells is implicated in the regulation of insulin secretion
stimulated by nutrient secretagogues or cyclic adenosine monophosphate ... Cited by 26 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] BA Cunningham, AMT Richard, JS Dillon, JT … - Biochemical Journal, 2003 - pubmedcentral.nih.gov Glucose-induced insulin secretion from isolated, perifused rat islets is
pulsatile with a period of about 5–10 min, similar to the insulin oscillations
that are seen in healthy humans but which are impaired in Type II diabetes. ... Cited by 24 - Related articles - BL Direct - All 7 versions
H Mulder, S Yang, MS Winzell, C Holm, B … - Diabetes, 2004 - Am Diabetes Assoc Lipids may serve as coupling factors in K ATP -independent glucose sensing in
β-cells. We have previously demonstrated that β-cells harbor lipase
activities, one of which is the hormone-sensitive lipase. Whether β-cell ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org MS Winzell, H Svensson, P Arner, B Ahrén, C … - Diabetes, 2001 - Am Diabetes Assoc Hormone-sensitive lipase (HSL) is expressed and enzymatically active in β-cells
and has been proposed to be involved in the generation of the lipid-derived
signal that seems to be necessary for glucose-stimulated insulin secretion. ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Roduit, P Masiello, SP Wang, H Li, GA … - Diabetes, 2001 - Am Diabetes Assoc Endogenous lipid stores are thought to be involved in the mechanism whereby the
β-cell adapts its secretory capacity in obesity and diabetes. In addition,
hormone-sensitive lipase (HSL) is expressed in β-cells and may provide ... Cited by 74 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] H Mulder, LS Holst, H Svensson, E Degerman … - Diabetes, 1999 - Am Diabetes Assoc Triglycerides in the -cell may be important for stim- ulus-secretion coupling,
through provision of a lipid- derived signal, and for pathogenetic events in
NIDDM, where lipids may adversely affect -cell function. In adipose ... Cited by 87 - Related articles - BL Direct - All 4 versions
H Lindvall, P Nevsten, K Ström, R Wallenberg … - Journal of Biological Chemistry, 2004 - ASBMB Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization in
many cell types. Two isoforms of HSL are known to date, namely HSL adi (84 kDa
in rat) and HSL tes (130 kDa in rat). These are encoded by the same gene, ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org ML Peyot, CJ Nolan, K Soni, E Joly, R Lussier … - Diabetes, 2004 - Am Diabetes Assoc We previously reported decreased glucose-stimulated insulin secretion (GSIS) in
hormone-sensitive lipase-null mice (HSL −/− ), both in vivo and in vitro.
The focus of the current study was to gain further insight into the ... Cited by 34 - Related articles - BL Direct - All 6 versions
GM Smith, AJ Garton, A Aitken, SJ Yeaman - FEBS letters, 1996 - Elsevier Hormone-sensitive lipase (HSL) is a multi-functional enzyme involved in several
aspects of lipid metabolism. Limited tryptic digestion of HSL led to selective
loss of activity against lipid substrates but not against the water-soluble ... Cited by 25 - Related articles - BL Direct - All 4 versions
