K Maedler, GA Spinas, D Dyntar, W Moritz, N … - Diabetes, 2001 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
unsaturated fatty acids at different glucose concentrations on β-cell ... Cited by 221 - Related articles - BL Direct - All 7 versions
K Maedler, J Oberholzer, P Bucher, GA … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
monounsaturated fatty acids at different glucose concentrations on human ... Cited by 149 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Cnop, JC Hannaert, A Hoorens, DL Eizirik, … - Diabetes, 2001 - Am Diabetes Assoc Studies in Zucker diabetic fatty rats have led to the concept that chronically
elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden
pancreatic β-cells as a result of the formation of ceramides, which induce ... Cited by 216 - Related articles - BL Direct - All 9 versions
R Lupi, F Dotta, L Marselli, S Del Guerra, M … - Diabetes, 2002 - Am Diabetes Assoc In an effort to better understand the phenomenon of lipotoxicity in human
β-cells, we evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l
free fatty acid (FFA) (2:1 oleate to palmitate) on the function and ... Cited by 268 - Related articles - BL Direct - All 7 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty
acids (FFAs) together with hyperglycemia are synergistic in causing islet
ß-cell damage because high glucose inhibits fat oxidation and consequently ... Cited by 173 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Federici, M Hribal, L Perego, M Ranalli, Z … - Diabetes, 2001 - Am Diabetes Assoc Type 2 diabetes is characterized by insulin resistance and inadequate insulin
secretion. In the advanced stages of the disease, β-cell dysfunction worsens
and insulin therapy may be necessary to achieve satisfactory metabolic ... Cited by 174 - Related articles - BL Direct - All 5 versions
S Piro, M Anello, C Di Pietro, MN Lizzio, G … - Metabolism, 2002 - Elsevier We investigated the effect of a chronic exposure to high levels of free fatty
acid (FFA; 2 mmol/L oleate/palmitate 2:1) or glucose (16.7 mmol/L) on islet cell
apoptosis. Apoptosis was detected using 4 different methods: (1) cell ... Cited by 121 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org K Maedler, GA Spinas, R Lehmann, P Sergeev … - Diabetes, 2001 - Am Diabetes Assoc In autoimmune type 1 diabetes, Fas–to–Fas-ligand (FasL) interaction may
represent one of the essential pro-apoptotic pathways leading to a loss of
pancreatic ß-cells. In the advanced stages of type 2 diabetes, a decline ... Cited by 195 - Related articles - BL Direct - All 5 versions
- ►nih.gov M Shimabukuro, YT Zhou, M Levi, RH Unger - Proceedings of the National Academy of Sciences of …, 1998 - National Acad Sciences Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early β cell
compensation for insulin resistance (4-fold β cell hyperplasia) followed by
decompensation (>50% loss of β cells). In prediabetic and diabetic ZDF ... Cited by 642 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org [PDF] MY Donath, DJ Gross, E Cerasi, N Kaiser - Diabetes, 1999 - Am Diabetes Assoc The gerbil Psammomys obesus develops nutrition- dependent diabetes associated
with moderate obesity. The disease is characterized by initial hyperinsulinemia,
progressing to hypoinsulinemia associated with depleted pancreatic insulin ... Cited by 224 - Related articles - BL Direct - All 5 versions
