PA Halban, SE Kahn, Å Lernmark, CJ Rhodes - Diabetes, 2001 - Am Diabetes Assoc Recent advances in molecular and cell biology may allow for the development of
novel strategies for the treatment and cure of type 1 diabetes. In particular,
it is now possible to envisage restoration of insulin secretion by gene or ... Cited by 66 - Related articles - BL Direct - All 7 versions
PA Halban, SE Kahn, Å Lernmark, CJ Rhodes - Diabetes, 2001 - Am Diabetes Assoc Recent advances in molecular and cell biology may allow for the development of
novel strategies for the treat- ment and cure of type 1 diabetes. In particular,
it is now possible to envisage restoration of insulin secretion by gene or ... Related articles
- ►endojournals.org P Muzzin, RC Eisensmith, KC Copeland, … - Molecular Endocrinology, 1997 - Endocrine Soc Type 1 diabetes mellitus is caused by a lack of insulin that results from the
autoimmune destruction of the pancreatic ß-cells. Severe diabetes, if not
controlled by periodic insulin injections, can lead to ketoacidosis and ... Cited by 52 - Related articles - BL Direct - All 4 versions
A Auricchio, GP Gao, QC Yu, S Raper, VM … - Gene therapy, 2002 - ncbi.nlm.nih.gov To test whether hepatocytes engineered in vivo can serve as surrogate beta cells
by similarly secreting mature insulin in a glucose-sensitive manner, we prepared
adenoviral vectors encoding wild-type proinsulin (hIns-wt), a modified ... Cited by 43 - Related articles - BL Direct - All 3 versions
H Dong, SLC Woo - Trends in Endocrinology & Metabolism, 2001 - Elsevier Type 1 diabetes, along with its long-term complications, imposes a serious
impact on public health. In spite of the development and application of various
insulin formulations, exogenous insulin neither achieves the same degree of ... Cited by 32 - Related articles - BL Direct - All 4 versions
HC Lee, SJ Kim, KS Kim, HC Shin, JW Yoon - Nature, 2000 - nature.com A cure for diabetes has long been sought using several different approaches,
including islet transplantation, regeneration of cells and insulin gene therapy
1 . However, permanent remission of type 1 diabetes has not yet been ... Cited by 201 - Related articles - BL Direct - All 9 versions
R Chen, ML Meseck, SLC Woo - Molecular Therapy, 2001 - Elsevier Paradigms of insulin gene therapy for type 1 diabetes should incorporate
vigorous control for insulin gene expression to be effective in correcting
postprandial hyperglycemia and to be safe in preventing fasting ... Cited by 47 - Related articles - BL Direct - All 5 versions
GC Weir - Seminars in Cell and Developmental Biology, 2004 - Elsevier Insufficient pancreatic β-cell mass is fundamental to the pathogenesis of both
types 1 and 2 diabetes and constitutes the basis for the goal of β-cell
replacement therapy. Current methods for isolating islets from organ donor ... Cited by 15 - Related articles - All 3 versions
PM Thule, JM Liu - Gene therapy, 2000 - ncbi.nlm.nih.gov Effective and safe insulin gene therapy will require regulation of transgenic
insulin secretion. We have created a liver-targeted insulin transgene by
engineering glucose responsive elements into a hepatic promoter containing ... Cited by 83 - Related articles - BL Direct - All 3 versions
