- ►diabetesjournals.org FA Khan, PB Goforth, M Zhang, LS Satin - Diabetes, 2001 - Am Diabetes Assoc Insulin is known to regulate pancreatic β-cell function through the activation of cell surface insulin
receptors, phosphorylation of insulin receptor substrate (IRS)-1 and -2, and activation of phosphatidylinositol
(PI) 3-kinase. However, an acute effect of insulin in modulating β-cell electrical activity ... Cited by 69 - Related articles - BL Direct - All 4 versions
PCT a Phosphatidylinositol - DIABETES, 2001 - Am Diabetes Assoc Insulin is known to regulate pancreatic -cell function through the activation of cell surface insulin
receptors, phosphorylation of insulin receptor substrate (IRS)-1 and -2, and activation of phosphatidylinositol
(PI) 3- kinase. However, an acute effect of insulin in modulat- ing -cell electrical activity ... Related articles
- ►ncue.edu.tw [PDF] SJ Persaud, H Asare-Anane, PM Jones - FEBS letters, 2002 - Elsevier There is no consensus on the role of insulin secreted from pancreatic β-cells in regulating its
own secretion, either in rodent islets or in human islets. We have now investigated whether there
is an autocrine signalling role for insulin in human islets by determining insulin receptor ... Cited by 47 - Related articles - All 7 versions
CA Aspinwall, WJ Qian, MG Roper, RN Kulkarni, … - Journal of Biological …, 2000 - ASBMB The signaling pathway by which insulin stimulates insulin secretion and increases in intracellular
free Ca 2+ concentration ([Ca 2+ ] i ) in isolated mouse pancreatic β-cells and clonal β-cells was
investigated. Application of insulin to single β-cells resulted in increases in [Ca 2+ ] i that ... Cited by 115 - Related articles - BL Direct - All 3 versions
GG Xu, ZY Gao, PD Borge Jr, PA Jegier, RA Young, BA … - Biochemistry, 2000 - ncbi.nlm.nih.gov The insulin receptor signaling pathway is present in beta-cells and is believed to be important
in beta-cell function. We show here that insulin directly regulates beta-cell function in isolated
rodent islets. Long-term insulin treatment caused a sustained increase in [Ca(2+)](i) and ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►jbc.org CA Aspinwall, JRT Lakey, RT Kennedy - Journal of Biological Chemistry, 1999 - ASBMB Functional insulin receptors are known to occur in pancreatic beta cells; however, except for
a positive feedback on insulin synthesis, their physiological effects are unknown. Amperometric
measurements at single, primary pancreatic beta cells reveal that application of ... Cited by 120 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org MG Roper, W Qian, BB Zhang, RN Kulkarni, CR Kahn, … - Diabetes, 2002 - Am Diabetes Assoc L-783,281, an antidiabetic fungal metabolite that has previously been shown to activate insulin
signaling in CHO cells, was tested for its effect on intracellular Ca 2+ ([Ca 2+ ] i ) and insulin secretion
in single mouse pancreatic β-cells. Application of 10 μmol/l L-783,281 for 40 s to isolated ... Cited by 23 - Related articles - BL Direct - All 5 versions
LA Velloso, EM Carneiro, SC Crepaldi, AC Boschero, … - FEBS letters, 1995 - Elsevier The presence of tyrosine-phospborylated proteins was studied in cultured rat pancreatic
islets. Immunoblotting performed with total extracts of islets cultured in the presence of 1.8 or
5.6 mM glucose revealed at least three distinct tyrosinephos-phosphorylated bands (25 ... Cited by 46 - Related articles - All 5 versions
PL Rothenberg, LD Willison, J Simon, BA Wolf - Diabetes, 1995 - Am Diabetes Assoc In the beta TC3 insulin-secreting beta-cell line, glucose rapidly induces the tyrosine phosphorylation
of the 97-kDa insulin receptor beta-subunit. Phosphorylation is transient, with fourfold stimulation
by 2 min and subsequent dephosphorylation to basal levels by 10-15 min. Elevating the ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►endojournals.org WS Zawalich, KC Zawalich - Endocrinology, 2000 - Endocrine Soc Wortmannin (5–100 nM), a specific phosphatidyinositol 3-kinase inhibitor, augmented 8 mM
glucose-induced insulin secretion from control Sprague Dawley rat islets in a dose-dependent
manner. This effect persisted after its removal from the perifusion medium; however, this ... Cited by 35 - Related articles - BL Direct - All 3 versions
