R Cazzolli, L Carpenter, TJ Biden, C Schmitz- … - Diabetes, 2001 - Am Diabetes Assoc We have shown previously that palmitate treatment of C2C12 skeletal muscle
myotubes causes inhibition of the protein kinase B (PKB) pathway and hence
reduces insulin-stimulated glycogen synthesis through the elevation of ... Cited by 87 - Related articles - BL Direct - All 5 versions
E Hajduch, A Balendran, IH Batty, GJ … - Diabetologia, 2001 - Springer The activation of phosphoinositide 3-kinase (PI3K) by insulin represents a key
signalling event in the hormonal stimulation of diverse cellular responses ...
Ceramide impairs the insulin-dependent membrane recruitment Cited by 91 - Related articles - BL Direct - All 3 versions
C Schmitz-Peiffer, DL Craig, TJ Biden - Journal of Biological Chemistry, 1999 - ASBMB We have employed C2C12 myotubes to investigate lipid inhibition of
insulin-stimulated signal transduction and glucose metabolism. Cells were
preincubated for 18 h in the absence or presence of free fatty acids (FFAs) ... Cited by 287 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] S Stratford, DB DeWald, SA Summers - Biochemical Journal, 2001 - pubmedcentral.nih.gov Numerous hormones, cytokines and transforming oncogenes activate
phosphoinositide 3-kinase (PI-3K), a lipid kinase that initiates signal
transduction cascades regulating cellular pro- liferation, survival, ... Cited by 53 - Related articles - BL Direct - All 8 versions
- ►jbc.org [PDF] J Turinsky, DM O'sullivan, BP Bayly - Journal of Biological Chemistry, 1990 - ASBMB Diacylglycerol and Ceramides in Rat Tissues in Vivo 16881 observed in isolated
muscles or perfused hindquarters of obese rats (14-16). The second series of
experiments was performed on normal Sprague-Dawley rats and investigated ... Cited by 100 - Related articles - All 3 versions
T Teruel, R Hernandez, M Lorenzo - Diabetes, 2001 - Am Diabetes Assoc Tumor necrosis factor (TNF)-α causes insulin resistance on glucose uptake in
fetal brown adipocytes. We explored the hypothesis that some effects of TNF-α
could be mediated by the generation of ceramide, given that TNF-α ... Cited by 81 - Related articles - BL Direct - All 4 versions
P Storz, H Doppler, A Wernig, K Pfizenmaier, … - European Journal of Biochemistry, 1999 - interscience.wiley.com Insulin resistance in skeletal muscle is one of the earliest symptoms associated
with non-insulin-dependent diabetes mellitus (NIDDM). Tumour necrosis factor
(TNF) and nonesterified fatty acids have been proposed to be crucial ... Cited by 66 - Related articles - BL Direct - All 6 versions
M Salinas, R López-Valdaliso, D Martı́n, A … - Molecular and Cellular Neuroscience, 2000 - Elsevier Accumulation of ceramide has been reported in stress- and receptor-induced
apoptosis in the nervous system. However, its role in apoptosis signaling
remains elusive. We describe here the inhibition of the NGF-activated ... Cited by 117 - Related articles - BL Direct - All 5 versions
- ►nih.gov SA Summers, LA Garza, H Zhou, MJ … - Molecular and Cellular Biology, 1998 - Am Soc Microbiol The sphingomyelin derivative ceramide is a signaling molecule implicated in
numerous physiological events. Recently published reports indicate that ceramide
levels are elevated in insulin-responsive tissues of diabetic animals and ... Cited by 197 - Related articles - BL Direct - All 5 versions
- ►nih.gov DJ Powell, E Hajduch, G Kular, HS Hundal - Molecular and Cellular Biology, 2003 - Am Soc Microbiol Ceramide is generated in response to numerous stress-inducing stimuli and has
been implicated in the regulation of diverse cellular responses, including cell
death, differentiation, and insulin sensitivity. Recent evidence indicates ... Cited by 75 - Related articles - BL Direct - All 4 versions
