- ►diabetesjournals.org H Heimberg, Y Heremans, C Jobin, R Leemans, … - Diabetes, 2001 - Am Diabetes Assoc Cytokine-induced β-cell death is an important event in the pathogenesis of type
1 diabetes. The transcription factor nuclear factor-κB (NF-κB) is activated by
interleukin-1β (IL-1β), and its activity promotes the expression of ... Cited by 129 - Related articles - BL Direct - All 4 versions
N Giannoukakis, WA Rudert, M Trucco, PD … - Journal of Biological Chemistry, 2000 - ASBMB Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that inhibits β cell
function and promotes Fas-triggered apoptosis. IL-1β is thought to act early in
the initiation of the autoimmune destruction of pancreatic β cells in type ... Cited by 127 - Related articles - BL Direct - All 4 versions
H Heimberg, Y Heremans, C Jobin, R Leemans, … - Diabetes, 2001 - Am Diabetes Assoc Page 1. Inhibition of Cytokine-Induced NF- B Activation by Adenovirus-Mediated
Expression of a NF- B Super-Repressor Prevents -Cell Apoptosis ... Cited by 50 - Related articles
AK Cardozo, H Heimberg, Y Heremans, R Leeman … - Journal of Biological Chemistry, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic
-cells. Cytokines, such as interleukin-1 and interferon- , are putative
mediators of immune-induced -cell death and, under in vitro conditions, ... Cited by 158 - Related articles - BL Direct - All 4 versions
MS Baker, X Chen, XC Cao, DB Kaufman - Journal of Surgical Research, 2001 - Elsevier Background. Islet graft injury by cytokines released from inflammatory cells
(macrophages) that infiltrate the transplant site is an important mechanism of
early islet transplant dysfunction. This detrimental “cytokine effect” ... Cited by 43 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org AK Cardozo, M Kruhøffer, R Leeman, T Ørntoft, … - Diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from the selective
destruction of insulin-producing β-cells. Cytokines may contribute to
pancreatic β-cell death in type 1 diabetes. β-cell exposure to ... Cited by 145 - Related articles - BL Direct - All 4 versions
MI Darville, DL Eizirik - Diabetologia, 1998 - Springer Type I (insulin-dependent) diabetes mellitus results from a selective
destruction of the pancreatic insu- lin-producing beta cells. Cytokines,
especially inter- leukin-1b (IL-1b), could play an important role in im- ... Cited by 113 - Related articles - BL Direct - All 3 versions
- ►nih.gov R Eldor, A Yeffet, K Baum, V Doviner, D Amar, … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences Type 1 diabetes is characterized by the infiltration of inflammatory cells into
pancreatic islets of Langerhans, followed by the selective and progressive
destruction of insulin-secreting beta cells. Islet-infiltrating leukocytes ... Cited by 50 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org [PDF] D Liu, D Pavlovic, MC Chen, M Flodström, S … - Diabetes, 2000 - Am Diabetes Assoc Prolonged exposure of rodent -cells to combinations of cytokines induces the
inducible form of nitric oxide synthase (iNOS) expression and Fas expression,
nitric oxide (NO) production, and cell death. It also induces the ... Cited by 165 - Related articles - BL Direct - All 5 versions
I Chang, S Kim, JY Kim, N Cho, YH Kim, HS … - Diabetes, 2003 - Am Diabetes Assoc Recent studies incriminating tumor necrosis factor (TNF)- as the final effector
in pancreatic ß-cell death in type 1 diabetes underscore the potential role of
TNF- -dependent NF- B activation as an important modulator of pancreatic ... Cited by 46 - Related articles - BL Direct - All 5 versions
