J Buteau, S Foisy, CJ Rhodes, L Carpenter, TJ Biden, … - Diabetes, 2001 - Am Diabetes Assoc Glucagon-like peptide-1 (GLP-1), an insulinotropic and glucoincretin hormone, is a potentially
important therapeutic agent in the treatment of diabetes. We previously provided evidence that
GLP-1 induces pancreatic β-cell growth nonadditively with glucose in a ... Cited by 138 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org J Buteau, S Foisy, E Joly, M Prentki - Diabetes, 2003 - Am Diabetes Assoc We previously provided evidence that glucagon-like peptide 1 (GLP-1) induces pancreatic
ß-cell growth nonadditively with glucose in a phosphatidylinositol (PI) 3-kinase- and protein kinase
C -dependent manner. However, the exact mechanism by which the GLP-1 receptor (GLP- ... Cited by 147 - Related articles - BL Direct - All 5 versions
J Buteau, R Roduit, S Susini, M Prentki - Diabetologia, 1999 - Springer Glucagon-like peptide-1-(7±36)amide (GLP-1) is se- creted by the enteroendocrine L-cells in
response to fat meals and carbohydrates [1, 2]. It is a potent glu- coincretin hormone which acts
as a competence fac- tor in determining the ability of the beta-cell to re- spond to glucose ... Cited by 236 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Hui, A Nourparvar, X Zhao, R Perfetti - Endocrinology, 2003 - Endocrine Soc The activation of the glucagon-like peptide-1 (GLP-1) receptor has been shown to have an important
role in the functional activity of islet ß-cells and in the expansion of the islet cell mass. Constant
remodeling of islet cell mass is mediated in vivo by proliferative and apoptotic stimuli to ... Cited by 145 - Related articles - BL Direct - All 4 versions
Y Li, T Hansotia, B Yusta, F Ris, PA Halban, DJ … - Journal of Biological …, 2003 - ASBMB Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and augments β cell mass via activation
of β cell proliferation and islet neogenesis. We examined whether GLP-1 receptor signaling modifies
the cellular susceptibility to apoptosis. Mice administered streptozotocin (STZ), an agent ... Cited by 254 - Related articles - BL Direct - All 7 versions
- ►endojournals.org C Montrose-Rafizadeh, P Avdonin, MJ Garant, BD … - Endocrinology, 1999 - Endocrine Soc Chinese hamster ovary (CHO) cells stably expressing the human insulin receptor and the rat
glucagon-like peptide-1 (GLP-1) receptor (CHO/GLPR) were used to study the functional coupling
of the GLP-1 receptor with G proteins and to examine the regulation of the ... Cited by 65 - Related articles - BL Direct - All 3 versions
- ►endojournals.org L Farilla, H Hui, C Bertolotto, E Kang, A Bulotta, U Di … - Endocrinology, 2002 - Endocrine Soc A constant remodeling of islet cell mass mediated by proliferative and apoptotic stimuli ensures
a dynamic response to a changing demand for insulin. In this study, we investigated the effect
of glucagon-like peptide-1 (GLP-1) in Zucker diabetic rats, an animal model in which the ... Cited by 193 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org DD De León, S Deng, R Madani, RS Ahima, DJ … - Diabetes, 2003 - Am Diabetes Assoc A reduction in β-cell mass is an important causative factor in type 1 and type 2 diabetes.
Glucagon-like peptide-1 (GLP-1) and the long-acting agonist exendin 4 (Ex-4) expand β-cell
mass by stimulating neogenesis and proliferation. In the partial pancreatectomy (Ppx) ... Cited by 105 - Related articles - BL Direct - All 6 versions
J Buteau, W El-Assaad, CJ Rhodes, L Rosenberg, E … - Diabetologia, 2004 - Springer Aims/hypothesis. We have provided evidence that gluca- gon-like peptide-1, a potential therapeutic
agent in the treatment of diabetes, activates phosphatidylinositol-3 kinase/protein kinase B signalling
in the pancreatic beta cell. Since this pathway promotes cell survival in a vari- ety of ... Cited by 113 - Related articles - BL Direct - All 4 versions
G Kang, OG Chepurny, GG Holz - The Journal of Physiology, 2001 - Physiological Soc CICR was triggered by the GLP-1 receptor agonist exendin-4, an effect mimicked by
caffeine, Sp-cAMPS or forskolin. CICR required influx of Ca 2+ through L-type voltage-dependent
Ca 2+ channels, and was blocked by treatment with nimodipine, thapsigargin, or ... Cited by 96 - Related articles - BL Direct - All 6 versions
