LJ Elrick, K Docherty - Diabetes, 2001 - Am Diabetes Assoc Pancreatic duodenal homeobox-1 (PDX-1) is a homeodomain protein that plays an
important role in the development of the pancreas and in maintaining the
identity and function of the islets of Langerhans. It also regulates the ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►jbc.org I Rafiq, G da Silva Xavier, S Hooper, GA … - Journal of Biological Chemistry, 2000 - ASBMB Exposure of islet -cells to elevated glucose concentrations (30 versus 3 mM)
prompts enhanced preproinsulin (PPI) gene transcription and the trans-location
to the nucleoplasm of pancreatic duodenum homeobox-1 (PDX-1; Rafiq, I., ... Cited by 70 - Related articles - BL Direct - All 5 versions
- ►jbc.org WM Macfarlane, CM McKinnon, ZA Felton- … - Journal of Biological Chemistry, 1999 - ASBMB One of the mechanisms whereby glucose stimulates insulin gene transcription in
pancreatic -cells involves activation of the homeodomain transcription factor
PDX1 (pancreatic/duodenal homeobox-1) via a stress-activated pathway ... Cited by 143 - Related articles - BL Direct - All 5 versions
- ►jbc.org I Rafiq, HJ Kennedy, GA Rutter - Journal of Biological Chemistry, 1998 - ASBMB Using laser-scanning confocal microscopy, we have monitored glucose-induced
changes in the subcellular localization of insulin promoter factor-1 (IPF-1)
labeled with a c-myc epitope tag. This construct trans-activated the ... Cited by 68 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] H Wu, WM MacFarlane, M Tadayyon, JR Arch, … - Biochemical Journal, 1999 - pubmedcentral.nih.gov Pancreatic–duodenal homoeobox factor-1 (PDX1) is a homoeo- domain
transcription factor that plays an important role in linking glucose metabolism
in pancreatic β cells to the regulation of insulin gene transcription. Our ... Cited by 58 - Related articles - All 8 versions
D Kawamori, Y Kajimoto, H Kaneto, Y … - Diabetes, 2003 - Am Diabetes Assoc Oxidative stress is induced in pancreatic β-cells under diabetic conditions and
causes β-cell dysfunction. Antioxidant treatment of diabetic animals leads to
recovery of insulin biosynthesis and increases the expression of its ... Cited by 67 - Related articles - BL Direct - All 4 versions
T Moede, B Leibiger, HG Pour, PO Berggren, … - FEBS letters, 1999 - Elsevier Pancreatic duodenal homeobox-containing transcription factor 1 (PDX-1) plays a
crucial role in pancreas development and β-cell gene regulation. Absence of
PDX-1 leads to pancreas agenesis and its malfunction causes MODY4 diabetes ... Cited by 69 - Related articles - All 5 versions
- ►endojournals.org X Wang, J Zhou, ME Doyle, JM Egan - Endocrinology, 2001 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) enhances insulin secretion and synthesis. It
also regulates the insulin, glucokinase, and GLUT2 genes. It mediates increases
in glucose-stimulated insulin secretion by activating adenylyl cyclase and ... Cited by 71 - Related articles - BL Direct - All 3 versions
B Hessabi, P Ziegler, I Schmidt, C Hessabi, R … - FEBS Journal, 1999 - ingentaconnect.com The b-cell homeodomain transcription factor PDX-1 has vital functions both in
controlling the expression of pancreatic polypeptide hormones and in the
development of the pancreas. The transactivating and DNA-binding properties ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►nih.gov DK Hagman, LB Hays, SD Parazzoli, V … - Journal of Biological Chemistry, 2005 - ASBMB Abnormalities in lipid metabolism have been proposed as contributing factors to
both defective insulin secretion from the pancreatic beta cell and peripheral
insulin resistance in type 2 diabetes. Previously, we have shown that ... Cited by 42 - Related articles - BL Direct - All 10 versions
