F Reimann, FM Ashcroft, FM Gribble - Diabetes, 2001 - Am Diabetes Assoc Nicorandil is a new antianginal agent that potentially may be used to treat the cardiovascular
side effects of diabetes. It is both a nitric oxide donor and an opener of ATP-sensitive K + (K ATP
) channels in muscle and thereby causes vasodilation of the coronary vasculature. The ... Cited by 45 - Related articles - BL Direct - All 5 versions
CL Lawrence, P Proks, GC Rodrigo, P Jones, Y … - Diabetologia, 2001 - Springer The sulphonylurea gliclazide is widely used in the treatment of Type II
(non-insulin-dependent) diabe- tes mellitus because of its ability to stimulate insulin secretion
from pancreatic beta-cells. Like other sul- phonylureas, its principal target is the ATP- ... Cited by 41 - Related articles - BL Direct - All 3 versions
DK Song, FM Ashcroft - British journal of pharmacology, 2001 - pubmedcentral.nih.gov This article has been cited by other articles in PMC. ... We examined the effect of the sulphonylurea
glimepiride on three types of recombinant ATP-sensitive potassium (K ATP ) channels. ... K ATP
channels share a common pore-forming subunit, Kir6.2, which associates with different ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org F Reimann, FM Gribble, FM Ashcroft - Molecular Pharmacology, 2000 - ASPET ATP-sensitive K-channels (K ATP channels) are the target for K ATP -channel openers
(KCOs), such as pinacidil and P1075. These channels are formed from pore-forming Kir6.2 and
regulatory sulfonylurea receptors (SUR2A in heart and skeletal muscle; SUR2B in smooth ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►cell.com F M. Ashcroft, F M. Gribble - Trends in Pharmacological Sciences, 2000 - Elsevier K ATP channel openers are a diverse group of drugs with a wide range of potential therapeutic
uses. Their molecular targets, the K ATP channels, exhibit tissue-specific responses because
they possess different types of regulatory sulfonylurea receptor subunits. It is well ... Cited by 106 - Related articles - All 6 versions
C Moreau, H Jacquet, AL Prost, ND'hahan, M … - The EMBO …, 2000 - pubmedcentral.nih.gov K ATP channels incorporate a regulatory subunit of the ATP-binding cassette (ABC) transporter
family, the sulfonylurea receptor (SUR), which defines their pharmacology. The therapeutically
important K + channel openers (eg pinacidil, cromakalim, nicorandil) act specifically on ... Cited by 85 - Related articles - BL Direct - All 4 versions
F Gribble, F Reimann - Biochemical Society Transactions, 2002 - bst.portlandpress.com Pharmacological modulation of ATP-sensitive K + (K ATP ) channels is used in the treatment
of a number of clinical conditions, including type 2 diabetes and angina. The sulphonylureas
and related drugs, which are used to treat type 2 diabetes, stimulate insulin secretion by ... Cited by 43 - Related articles - Cached - BL Direct - All 10 versions
FM Gribble, FM Ashcroft - Diabetologia, 1999 - Springer Aims/hypothesis. To investigate the tissue specificity of gliclazide for cloned beta-cell, cardiac
and smooth muscle ATP-sensitive K-channels (K ATP channels). These channels share a common
pore-forming sub- unit, Kir6.2, which associates with different sulpho- nylurea receptor ... Cited by 69 - Related articles - BL Direct - All 3 versions
[CITATION] The interaction of nucleotides with the tolbutamide block of K-ATP currents: a …
- ►diabetesjournals.org M Dabrowski, FM Ashcroft, R Ashfield, P Lebrun, B … - Diabetes, 2002 - Am Diabetes Assoc ATP-sensitive K + (K ATP ) channels are activated by a diverse group of compounds known as
potassium channel openers (PCOs). Here, we report functional studies of the Kir6.2/SUR1 Selective
PCO 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide (NNC ... Cited by 24 - Related articles - BL Direct - All 4 versions
