- ►diabetesjournals.org B Brunmair, F Gras, S Neschen, M Roden, L … - Diabetes, 2001 - Am Diabetes Assoc Thiazolidinediones (TZDs) are believed to induce insulin sensitization by
modulating gene expression via agonistic stimulation of the nuclear peroxisome
proliferator–activated receptor- (PPAR- ). We have shown earlier that the ... Cited by 81 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org C Furnsinn, B Brunmair, S Neschen, M Roden … - Journal of Pharmacology and Experimental …, 2000 - ASPET Troglitazone is a nuclear peroxisome proliferator-activated receptor- agonist
with insulin-sensitizing properties that has been introduced for the treatment
of type 2 diabetes. To further elucidate its mechanism of action, this ... Cited by 24 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org [PDF] M Wang, SC Wise, T Leff, TZ Su - Diabetes, 1999 - Am Diabetes Assoc Troglitazone is an antidiabetic agent of the thiazo- lidinedione family. It is
generally believed that thiazo- lidinediones exert their insulin-sensitizing
activity through activation of peroxisome proliferator- activated receptor- ... Cited by 104 - Related articles - BL Direct - All 4 versions
- ►physiology.org JR Colca, WG McDonald, DJ Waldon, JW … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Thiazolidinediones address underlying causes of type 2 diabetes, although their
mechanism of action is not clearly understood. The compounds are thought to
function as direct activators of the nuclear receptor PPAR (peroxisome ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org B Brunmair, K Staniek, F Gras, N Scharf, A … - Diabetes, 2004 - Am Diabetes Assoc Metformin and thiazolidinediones (TZDs) are believed to exert their antidiabetic
effects via different mechanisms. As evidence suggests that both impair cell
respiration in vitro, this study compared their effects on mitochondrial ... Cited by 110 - Related articles - BL Direct - All 5 versions
C Dello Russo, V Gavrilyuk, G Weinberg, A … - Journal of Biological Chemistry, 2003 - ASBMB Activation of peroxisome proliferator-activated receptors (PPARs) can regulate
brain physiology and provide protection in models of neurological disease;
however, neither their exact targets nor mechanisms of action in brain are ... Cited by 68 - Related articles - BL Direct - All 4 versions
F Gras, B Brunmair, M Roden, W Waldhäusl, C … - British journal of pharmacology, 2003 - pubmedcentral.nih.gov Exposure of isolated skeletal muscle to troglitazone has resulted in
inconsistent findings ranging from inhibition to stimulation of fuel oxidation
and the glycogenic pathway. To better understand such variation in outcome, ... Related articles - BL Direct - All 4 versions
K Preininger, H Stingl, R Englisch, C … - British journal of pharmacology, 1999 - pubmedcentral.nih.gov During BSA-free perfusion, high dose troglitazone increased basal (P<0.01), but
inhibited glucagon-stimulated incremental glucose production by ~75% (10.0±2.5
vs control: 40.0±7.2 μmol g liver −1 , P<0.01). In parallel, ... Cited by 24 - Related articles - BL Direct - All 4 versions
BS Cha, TP Ciaraldi, L Carter, SE Nikoulina, … - Diabetologia, 2001 - Springer Skeletal muscle is the principal tissue for insulin-me- diated glucose disposal
and a major site of peripheral insulin resistance in patients with Type II
(non-insu- lin-dependent) diabetes mellitus [1, 2]. The thiazol- idinedione ... Cited by 66 - Related articles - BL Direct - All 5 versions
C Fürnsinn, B Brunmair, M Meyer, S Neschen, … - British journal of pharmacology, 1999 - pubmedcentral.nih.gov New thiazolidinediones BM13.1258 and BM15.2054 were studied with regard to their
PPARγ-agonistic activities and to their acute and chronic effects on glucose
metabolism in soleus muscle strips from lean and genetically obese rats. Cited by 20 - Related articles - BL Direct - All 4 versions
